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Investigator, Functional Genomics

Collegeville, PA
Closing date
Dec 6, 2021

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Life Sciences, Genomics
Job Type
Group Leader/Principal Investigator
Organization Type
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Site Name: USA - Pennsylvania - Upper Providence Posted Date: Sep 30 2021 The Genome Biology Department within GSK Functional Genomics is seeking an Investigator with well-documented expertise in CRISPR technologies, application, and analysis in order to develop and apply advanced genetic engineering and functional genomics platforms. The Investigator will function within a highly dynamic team that delivers functional genomics solutions to GSK's Oncology pipeline and will be responsible for establishing a broad methodological tool set for multi-omic disease model characterization or custom genetic screening (CRISPR, RNAi, ORF) applications. Genome Biology spans the interface of human genetics, functional genomics, molecular biology, cellular and tissue profiling, disease model engineering, high content screening and advanced novel tool building. The successful candidate will possess a deep knowledge of methods for CRISPR technologies (CRISPR KO, CRISPRi and CRISPRa) and quality control, as well as operation of standard functional genomics screening and molecular biology. Candidates with hands-on experience in employing single cell technologies, advanced flow cytometry knowledge and CRISPRa/i experience will be prioritized. Proficiency in setting up genome wide CRISPR screens is desirable. Practical understanding of NGS data processing and analytics is a significant plus, as is experience with lab automation. Responsibilities Regular collaboration with the key stakeholders; help group leader to steer project toward goals; and when needed help junior team members Help Reagent development groups, Translational Genomics-affiliated research units and Genome biology groups Broaden the application or improve the quality of cell engineering and functional genomics platforms through effective implementation of CRISPR and other technologies Actively pursue new technology platforms and engage with external partners for access to equipment, reagents, and/or services relevant to gene editing or functional screens Function independently to explore new technologies and share findings in research publications or presentations at renowned conferences Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: PhD in Genetics, Molecular Biology, Developmental Biology, Biochemistry, Oncology, Infectious Disease, Regenerative Medicine, Neuroscience, or related fields. 3yrs of post PhD experience with increased responsibilities in academia or industry Experience with preparation and quality control of CRISPR libraries and running of genome wide CRISPR screens Experience in NGS data analytical pipeline and proficiency with, R and PYTHON Preferred Qualifications: If you have the following characteristics, it would be a plus: Expertise in related fields as demonstrated by several first author publications in leading journals Proficiency in design and execution of CRISPR activation and/or inhibition screens Working knowledge of NGS platforms (Illumina, Oxford Nanopore, PacBio, etc.) and their applications Working knowledge of single cell applications including flow cytometry Documented experience with some or all of the following: DNA nucleases (CRISPR, ZFN, TALEN), cell culture, RNA interference, reporter gene assays, molecular cloning, RNA/DNA/protein quantification, epigenetics, lab automation, and/or viral vectors Experience with biostatistics, bioinformatics, and/or advanced data visualization is desirable Experience with cancer cell lines and oncology Pro-active collaborator with excellent communication skills, both written and verbal A passion for technology development and improving workflows Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness GSKGenetics *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
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