Investigator - LC-MS Protein Characterization
Site Name: USA - Pennsylvania - Upper Providence Posted Date: Oct 15 2021 GlaxoSmithKline has an immediate opening for an Investigator position - LC-MS and protein characterization in Collegeville, PA. The mass spectrometry group is well equipped with modern instrumentation including Synapt G2S with both H/DX and IM, Xevo G2-XS, Orbitrap Fusion Tribrid, Orbitrap XL, Exploris 480, Eclipse Tribrid, Q Exactive Plus, 2D-NanoUPLC, Nano-UPLC, UPLC and many other supporting instrumentation and associated data analysis software. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following… Developing mass spec-based analytical strategies & methods (e.g. LC-MS and LC-MS/MS) Perform analysis for the characterization and comparability evaluation of therapeutic proteins. Apply advanced methods and techniques, including immunoprecipitations and/or other small-scale purifications Develop other analytical and/or biochemical methods to deepen the understanding of protein structure -function relationships Represent the group in project matrix teams to provide Subject Expert Matter (SME) inputs in supporting clinical studies through commercial biopharmaceutical process development and manufacturing. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: MS with 8 years of experience in biotech or pharmaceutical industry or a Ph.D with 3 years of experience Experience in protein characterization mass spectrometry, with hands-on experience on various high-resolution accurate mass LC-MS instruments operation, nano-LC fluidics and LC-MS/MS methods, data processing software and workflows. Experience in mass spectrometry instrumentation, maintenance, and troubleshooting Prior knowledge and experience in participating and supporting biopharmaceutical analytical development at different stages Preferred Qualifications: If you have the following characteristics, it would be a plus: Experience in analysis of protein therapeutics using platform assays like intact/reduced, peptide mapping and advanced/novel technologies Scientific working knowledge in the structure and function of protein therapeutics Knowledge and hands-on experience in various separation techniques such as immunoprecipitation or other in vitro purification, CE, SEC, IEX and HPLC/UPLC Experience supporting FTIH through commercial stage of biopharmaceutical development The candidate is expected to be highly motivated with excellent communication skills, both written and verbal. Candidate should be an instinctive team player with excellent people skills. Experience in developing cutting-edge LC-MS/MS workflows for therapeutic proteins including mAbs, ADCs, and bispecifics is highly desirable. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. 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