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Investigator / Biochemist

Collegeville, PA
Closing date
Dec 3, 2021

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Life Sciences, Biochemistry
Job Type
Group Leader/Principal Investigator
Organization Type
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Site Name: USA - Pennsylvania - Upper Providence Posted Date: Nov 16 2021 We are recruiting an experienced and highly motivated scientist with expertise in biochemistry/enzymology to join the department of Screening, Profiling & Mechanistic Biology (SPMB) at GSK's research facility in Collegeville, Pennsylvania. The primary responsibility of the SPMB department is to deliver high quality, biologically relevant pre-clinical leads for all GSK therapeutic areas, by employing a combination of scientific tools and methodologies, including but not limited to activity and binding assay development, high-throughput screening, compound profiling for SAR, and mechanism of action studies. The candidate will provide enzymology support to GSK Research Unit programs from target selection through declaration of a clinical candidate. S/he will characterize novel enzymes, contribute to hit identification strategies, design and develop assays for hit identification, execute and triage small molecule discovery campaigns, and perform mechanism-of-action studies on qualified hits. The candidate will provide enzyme and small molecule mechanistic data and insight as part of a project team. S/he will collaborate in a highly multidisciplinary/matrix environment for the progression of drug discovery projects. The successful candidate is expected to drive and lead project strategy and direction in collaboration with Research Units and Chemistry project leaders, as well as represent SPMB and the target team at internal and external meetings. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: A Ph.D. degree, or Master's degree with at least 5 of years of experience, in biochemistry, enzymology, biophysics, chemistry, or a related field is required Preferred Qualifications: Extensive laboratory experience and strong theoretical background are required in one or more of the following fields: biochemical assay development, mechanistic characterization of enzymes and their ligands, protein biochemistry, biophysics, and chemical biology Ability to formulate and clearly articulate research plans Track record of strategic scientific leadership Influences and leads experimental design to solve complex problems; for example, applying biochemistry and enzymology expertise to: identify fit for purpose protein reagent novel assay design qualify and characterize hits from screening campaigns Self-directed learning ability and drive for scientific excellence Strong record of peer-reviewed publications is required Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
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