GSK

Investigator

Employer
GSK
Location
Collegeville, PA
Salary
Competitive
Posted
November 19 2021
Ref
312626
Discipline
Other, Other
Organization Type
Pharma
Site Name: USA - Pennsylvania - Upper Providence Posted Date: Nov 19 2021 GlaxoSmithKline has an immediate opening for an Investigator in degradation chemistry within the CMC Analytical department at our Collegeville, PA site. Job Purpose This position will provide degradation chemistry support for projects across all phases of pharmaceutical development (pre-CS to commercial), working in collaboration with the Team Leader to design and execute forced degradation (stress testing) experiments to elucidate degradation mechanisms and facilitate structural characterization of degradation products. The role may support and/or lead investigations to resolve issues with drug product stability, such as excipient incompatibility or formulation/packaging strategies. This is a laboratory-based role and will require good laboratory practices and documentation standards. Colleagues in the group support mass spectrometry analysis as well as forced degradation studies for therapeutic proteins (e.g. monoclonal antibodies). While these activities are not necessarily requirements for the position, there will be ample opportunities for cross-training in these areas if desired. Why you? Basic Qualifications: PhD/MS in organic or analytical chemistry, or equivalent experience Solid understanding of organic reaction mechanisms Strong analytical skills, preferably in chromatography Proven track record of expertise in organic or analytical chemistry supported by publications and presentations Preferred Qualifications: Background in HPLC/UV and/or HPLC/MS method development, validation, and sample analysis Experience in the structural characterization of small molecules Ability to predict likely pathways of degradation for drug molecules based on molecular structure Ability to design and execute experiments to understand and investigate potential degradation pathways Appropriate knowledge of regulatory requirements for forced degradation (stress testing) studies of pharmaceuticals Strong communication and interpersonal skills Ability to present results to customers and influence project team decisions related to degradation risks and potential mitigation strategies Project leadership skills Ability to work on complex technical problems in a team setting Self-motivated researcher with excellent organizational skills and ability to communicate in a scientific manner Why GSK? At GSK, we have already delivered unprecedented change over the past four years, improving R&D, becoming a leader in Consumer Health, strengthening our leadership, and transforming our commercial execution. Now, we're making the biggest changes we've made to our business in over 20 years. We're on track to separate and create two new companies in 2022: New GSK with a leading portfolio of vaccines and specialty medicines as well as R&D based on immune system and genetics science; and a new world-leading consumer healthcare company of loved and trusted brands. With new ambition comes new purpose. For New GSK, this is to unite science, talent and technology to get ahead of disease together - all with the clear ambition of delivering human health impact; stronger and more sustainable shareholder returns; and as a new GSK where outstanding people thrive. Getting ahead means preventing disease as well as treating it. How we do all this is through our people and our culture. A culture that is ambitious for patients - so we deliver what matters better and faster; accountable for impact - with clear ownership of goals and support to succeed; and where we do the right thing. So, if you're ready to improve the lives of billions, join us at this exciting moment in our journey. Join our challenge to get Ahead Together. *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

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