Site Name: USA - Pennsylvania - Upper Providence Posted Date: Nov 24 2021 An exciting opportunity has arisen for a highly motivated molecular biologist with a passion for protein technology, to join the department of Protein, Cellular, and Structural Sciences (PCSS) at GSK's facility in Upper Providence, Pennsylvania. The primary responsibility of the department is to design, generate and validate biological reagents for discovery activities across all of GSK's therapeutic modalities. The department also provides the structural and mechanistic understanding of drug target, molecular recognition and mode of action to deliver the best molecule. In this role, the scientist will have the opportunity to work on targets supporting multiple therapeutic areas including Oncology, Immunology, Infectious Disease, Neurology and Inflammation. The successful candidate will be responsible for downstream characterization and registration of genome-edited cell reagents for use in GSK's drug discovery platforms. Key Responsibilities include, but are not limited to: Run cell characterization for cell reagent QC using molecular biology skills (PCR, sequencing, Western and Seq editing software) Maintain, QC and register a variety of cell lines Troubleshoot technical issues, keep updated with latest technologies and improve experimental procedure accordingly Work comfortably with a fast-paced and productivity-oriented laboratory environment Work in a matrix team environment to enable optimal delivery of project and department objectives to the highest possible scientific standard Independently execute laboratory experiments and/or advanced data analysis, integration and interpretation with an emphasis on providing appropriate context for data and experiments in the progress of programs and/or platforms Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety training and practice Why you? Basic Qualifications: A Bachelor OR Master's degree in a life sciences discipline (e.g. molecular biology, cell biology, oncology) with at least 2+ years of relevant laboratory experience. Preferred Qualifications: Qualified candidates should have strong track-record in either one or more of the following disciplines: Molecular Biology, Cell Biology, Genetics If you have the following characteristics, it would be a plus: Extensive cell culture including cell lines, primary cells, co-culture models and iPSC Practical experience in CRISPR editing or other genome editing technologies Sequencing (Sanger and NGS), genotyping, primer/probe design, qRT-PCR, ddPCR and Snapgene/Benchling (or equivalent software) Advanced data analysis experience, e.g. Excel or Spotfire. Ability to plan and execute multiple tasks concurrently and evaluate multiple scientific strategies in parallel where appropriate Demonstrated strengths in high performance behaviours, such as building relationships, flexible thinking, and enabling/driving change. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. At GSK, we're a company with a special purpose, to help people do more feel better and live longer. Realising our purpose starts with us. When we feel at our best, we perform at our best. When you set out on your adventure at GSK, we make a deal. You commit to living GSK's values and expectations and performing against our Innovation, Performance and Trust priorities. And in return, GSK commits to providing the right environment for you to thrive. Put simply, it's about you being motivated to do your best work, in a place where you can be you, feel good and keep growing. Together we build an environment where we can all thrive and focus on what matters most to each of us. 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