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Postdoctoral Fellow - Inflammation & Immunology

Cambridge, Massachusetts
Closing date
Dec 3, 2021

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Life Sciences, Immunology
Position Type
Full Time
Job Type
Postdoc Fellowship
Organization Type
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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

The interleukin receptor-associated kinases 4 and 1 (IRAK4 and IRAK1) are key nodes in the response to pathogens (innate immunity) and in autoimmune and inflammatory disease. At Pfizer we have developed the first selective inhibitor of IRAK4 to advance to clinical trials as a potentially transformative therapy for diseases such as rheumatoid arthritis, SLE, and cancer. IRAK4 and IRAK1 a critical components of the toll-like receptor (TLR) and interleukin receptor signaling cascade that detect both pathogens and self-produced inflammatory proteins such as IL1 and IL18. However, a clear mechanistic understanding of the IRAKs in inflammatory signaling has been elusive and is the subject of intense interest in both academia and the pharmaceutical industry. Gaining a clearer understanding of the mechanistic role of IRAK kinase activity is critical for the further development of IRAK inhibitors and the identification of other potential therapeutic targets in inflammation. The post-doctoral fellow will utilize Pfizer's extensive resources and world leading expertise in innate immunity to better elucidate the role of IRAK4 in human biology and disease.

How You Will Achieve It

- Design and perform experiments designed to understand the role of the IRAK kinases in IL1 and TLR signaling.

- Collaborate and interact with external researchers in academia to investigate the role of IRAK4 in innate immune signaling and human disease

- Collaborate and interact with Pfizer colleagues in other therapeutic areas, chemistry, PDM, and bioinformatics to understand the biology around IRAK4.

- Present work at internal and external meetings and symposia

- Take the lead on drafting, writing, and submitting papers for academic journals detailing findings



  • Ph.D. in biochemistry, cell biology, immunology or related field. Must have strong written and oral communication skills.


  • Familiarity with immunology and cell biology techniques such as isolation of primary cells, disease relevant assays, and in vivo procedures are a plus but not required.





Relocation support available

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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