Senior Scientist, Translational Modeling & Simulation

Cambridge, Massachusetts
November 25 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best - in - class medicines to patients around the world.

What You Will Achieve

At Pfizer we deliver b reakthroughs t hat c hange p atients ' l ives. In this role, you'll be joining a team which plays a vital role in this mission through model-based drug development (MBDD) a mathematical and statistical approach that constructs, validates and utilizes disease, placebo, exposure-response and pharmaco - metric models to evaluate risk and facilitate drug development, in close collaboration with R&D partners.

As a Senior Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be recognized as a technical expert and a scientific contributor. With your deep knowledge of the discipline, you will be an active team member whose decisions impact the project. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will be forecasting and planning resource requirements for your project team. Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide team members.

It is your hard work and dedication that will make Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It
  • Apply technical and functional knowledge to design experiments and independently complete work within own work group/ project team, working on multiple subprojects in parallel.
  • Act as a technical and scientific resource within own project team/discipline.
  • Collaborate with multidisciplinary project teams to develop and implement mechanistic mathematical models of pharmacology to aid in target selection, target prioritization, therapeutic modality selection, chemical/biotherapeutic optimization, biomarker characterization and early clinical trial design.
  • Liaise with research biology/pharmacology to help in the development of in-vitro assays and in-vivo models to generate data that inform pre-clinical to clinical translated PKPD models.
  • Provide expert support to project teams to design, execute and interpret quantitative pharmacology studies.
  • Collaborate and maintain an active relationship with Clinical Pharmacology and Pharmacometrics at the project level as well as in the advancement of modeling and simulations sciences.
  • Network as appropriate with global experts in the department and other groups to share learnings and enhance consistency in best practices across sites, disease areas and therapeutic approaches.
  • Keep up to date with emerging literature and science in the systems pharmacology modeling and simulation sciences.


  • Ph.D. degree with 0-3 years of experience with a degree concentration in mathematics, engineering or other disciplines with a strong quantitative analysis component, preferably with an emphasis on biological/biopharmaceutical modeling and simulation
  • Excellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation
  • Ability to effectively translate/condense/summarize outcomes of modeling and simulation analyses into useable information for multidisciplinary project teams
  • Good team player and communicator
  • Good listener and ability to effectively interact with colleagues with a variety of backgrounds
  • Keen to interact as a modeling and simulation expert with matrix project teams working closely with within departmental as well as biology, protein engineering and clinical scientists
  • In depth, hands-on knowledge of the state-of-the-art modeling and simulation software (e.g., NONMEM, MATLAB, Simbiology, Phoenix, Berkeley-Madonna, R)
  • Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop mechanistically relevant PKPD models
  • Ability to keep up to date with and propose the implementation of scientific and technological developments in the area of PKPD modeling and simulation


  • Understanding of the basic principles of pharmacokinetics (non-compartmental, compartmental, PBPK)
  • Familiarity with standard (e.g., monoclonal antibody, Fc-fusion proteins) and novel (e.g., bispecifics antibodies, gene therapies) biotherapeutic modalities

Other Job Details:
  • Last Date to Apply for Job: November 30, 2021
  • Eligible for Employee Referral
  • Eligible for Relocation Package


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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