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PD Downstream Associate Scientist

Spark Therapeutics
Philadelphia, Pennsylvania
Salary not provided
Closing date
Feb 26, 2022

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Health Sciences, Drug Development
Job Type
Staff Scientist
Organization Type
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Job Details

The downstream process development (DSPD) team is seeking a highly motivated associate scientist with relevant industry experience to join the team. The successful candidate will participate in multiple downstream process development programs in Spark's innovative pipeline.


Describe the essential daily job functions and include % of time spent on each.

Job Function and Description


  • Lab-based experiments, including both bench scale and pilot scale operations.


  • Prepare experiment summary, process development reports and tech transfer documents


  • BS or MS in biochemistry, chemistry, chemical engineering, bioengineering, or related area with 0-3 years of relevant industry experience
  • Knowledge of downstream process development of the biologics, such as viral vectors, monoclonal antibodies, vaccines, and therapeutic recombinant proteins in the biopharma industry
  • Hands-on experience with operating chromatography and filtration systems
  • Working knowledge and skills for viral vector or vaccine purification is a plus.
  • Working knowledge of analytical techniques for in process testing or product characterization is a plus
  • Working knowledge of statistical design of experiments and data analysis is a plus


Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.

Nearest Major Market: Philadelphia

Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.


At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
3737 Market Street
Suite 1300
United States
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