Senior Scientist, Enzymology DMPK

Groton, Connecticut
November 23 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist
Pfizer is seeking a dynamic and collaborative experimental scientist for a Senior Scientist position contributing to ADME (absorption, disposition, metabolism and excretion) sciences in the in vitro enzymology and preclinical pharmacokinetics (PK) group.

The individual will be joining a dynamic group in ADME Sciences Enzymology, Department of Medicine Design, in support of the global Pfizer small molecule discovery research and development portfolio. The qualified candidate will be responsible for design, conduct and advancing in vitro enzymology, oversight of nonclinical pharmacokinetic studies, and/or modeling and simulation studies in support of ADME principles for programs. The individual will be a member of matrix teams comprised of other ADME discipline scientists and led by a project representative, with expectations that integrated information resolves ADME issues and advances programs. The role includes supervision and mentorship of laboratory staff, responsibility for experimental conduct or oversight, and resource management relevant to our therapeutic areas. The individual will also be expected to advance scientific understanding, grow effective partnerships externally as well as internally to incorporate growing technological advances, and incorporate novel experimental approaches to address challenging dispositional issues.

  • Provide scientific leadership and enzymology knowledge or expertise for lab-based portfolio support and scientific innovation relevant to ADME sciences. Relevant areas include understanding of drug clearance, tissue binding and disposition, reaction phenotyping, enzyme kinetics, enzyme inhibition/induction or relevant DDI data generation, pharmacokinetic data analysis, and delivery or conduct of quality preliminary or definitive ADME studies in support of regulatory filings.
  • Working with modeling and simulation scientists, take scientific leadership for the predictions of clearance (IVIVE) and drug-drug interactions. This includes directing or undertaking physiologically based PK (PBPK) modeling strategies, which support and achieve project goals or address regulatory interactions.
  • Advise discovery and development project teams regarding approaches to understand and optimize dispositional attributes and to address any regulatory filings for clinical candidates.
  • Guide and develop laboratory-based scientists focused on the design and conduct of novel low- and medium-throughput in vitro assays to support discovery and definitive development assays for regulatory filings.
  • Review and approve DMPK study protocols, research reports, nonclinical ADME summaries, and abstracts/manuscripts for publication.
  • Direct original research aligned with the research priorities established by the Medicine Design Strategic Imperatives and Business Plan, as well as ongoing assay conduct to support the Pfizer discovery and development portfolio.

Basic Qualifications
  • PhD or equivalent with 0-3 years of relevant postdoctoral academic or industry experience in the scientific field. Candidates with a diverse scientific background (eg pharmaceutical sciences, drug metabolism, pharmacokinetics, biochemistry, chemistry, biology, biomedical sciences, or engineering) are encouraged to apply.
  • A keen interest in growing knowledge and optimizing dispositional attributes of small molecules through ADME enzymology science and technology is required.
  • Strong leadership and interpersonal skills as well as a track record of enthusiasm to deliver results in a fast-paced environment.
  • Highly effective written, presentation and verbal communication skills are essential. Recognition for creativity and innovation through strong publication/presentation record.

Position Requirements
  • Periodic travel will be required to other Pfizer sites (eg Cambridge, MA; La Jolla, CA) or to attend and present at scientific conferences.
  • Conduct of experiments will require the scientist to work in a laboratory environment.

Additional Job Information:
  • Eligible for relocation support
  • Eligible for employee referral bonus


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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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