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Postdoctoral Fellow, Structural Biology and Biophysics

Groton, Connecticut
Closing date
Nov 27, 2021

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Life Sciences, Biophysics, Structural Biology
Position Type
Full Time
Job Type
Postdoc Fellowship
Organization Type
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We are seeking an enthusiastic and driven postdoctoral fellow to join the Structural and Molecular Sciences (SMS) Department at the Pfizer campus in Groton, Connecticut. This fellowship offers the unique opportunity to learn about the drug and vaccine development process in the laboratories of an innovative industry leader. The successful candidate will receive state-of-the-art training in protein structural biology and biochemistry with access to unparalleled resources supporting prokaryotic and eukaryotic protein expression, purification, and structure determination by X-ray crystallography or cryo-EM.At SMS, we have regular access to all the major synchrotron beam lines in the world and dedicated in-house cryo-EM facilities. Ideal candidates will have experience in molecular biology, protein expression, protein purification, and structure determination.


  • Purification and assembly of challenging protein-protein, protein-RNA and protein-small molecule complexes

  • Iterative design and cloning to generate protein expression constructs

  • Determine the structure of a functional complex to by X-ray crystallography or cryo-EM

  • Structural analysis to generate and test hypotheses

  • Functional characterization of protein complexes by biophysical and biochemical methods

  • Collaboration across departments

  • Critical reading of the relevant literature

  • Manuscript preparation and presentation of results in oral and poster formats


  • PhD in Structural Biology or Biochemistry with experience in the gene-to-structure pipeline

  • Construct design and molecular biology skills

  • Extensive experience in protein expression and purification

  • Experience with structure determination by X-ray crystallography and/or cryo-EM

  • Strong track record of publication in peer-reviewed scientific journals

  • Excellent verbal and written communication skills


  • Experience in biophysical and biochemical assay development

Relocation support available


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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