Pfizer

Senior Scientist, Early Antibody Discovery

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Posted
November 23 2021
Ref
4822504
Position Type
Full Time
Organization Type
Pharma
Job Type
Senior Scientist
Our mission

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development (R&D) is at the heart of Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. When you are in R&D, ensuring drug safety and efficacy, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Senior Scientist, you will be at the center of Early Antibody Discovery (EAD) and you'll find that everything we do is in line with an unwavering commitment to quality. You will lead the development and validation of biochemical assay and of cell-based functional assay in support of Pfizer's BioMedicine (BMD) programs. You will be responsible for designing and executing experiments based on homogenous technology including HTRF/LANCE/DELFIA/Alpha Screen. Develop cell-based functional assays for high-throughput screening (HT) and convert existing biochemical and cell-based assays into HT format. You will be analyzing data, writing reports and presenting results at internal meetings.

The responsibilities also include ensuring that all the work that you do is in compliance with relevant Standard Operating Procedures (SOPs) and Good Lab practices (GLP) guidelines. You will be recognized as a technical expert and a scientific contributor. With your deep assay development expertise, you will be an active team member whose findings impact the project. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. Your creativity in developing novel assay will be used frequently. It is your innovative scientific temperament that will help in making Pfizer ready to achieve new breakthroughs for patients across the globe .

How You Will Achieve It
  • Regularly contribute at the project team level to make it successful.
  • Utilize expertise in cell biology to develop robust cell-based assays for understanding cellular activity and the role of target of interest as well as for identifying and characterizing therapeutic hits. Proactively gather input from literature to drive projects forward.
  • Develop assays utilizing appropriate high-throughput detection technologies including FRET, luminescence (enzyme complementation), fluorescence, and flow cytometry.
  • Apply fit-for-purpose assay development and effectively balance assay rigor against project goals.
  • Participate in all phases of EAD operations including validation of assay reagents, data analysis, interpretation, reporting and follow up discussions with the project teams on utilizing the data in appropriate decision making.
  • Effectively interact with the Research Unit team and support projects advancement.
  • Develop partnerships and collaborations in a matrix environment, influencing project strategies and platform development.
  • Author and review laboratory methods and reports.
  • Keep abreast of scientific/ technological development by participating in scientific meetings/ seminars.


Qualifications

Must-Have
  • Bachelor's Degree with 8+ years of experience, Master's Degree with 5+ years of experience or PhD with 0-3 years of experience in molecular biology/immunology/cell biology or a related discipline
  • Industry experience in the field of biopharmaceuticals or immunology • Demonstrated and detailed knowledge and application of sample preparation methods as applied to flow cytometry techniques
  • Good understanding of immunology and cellular biology
  • Demonstrated experience with assay development
  • Proficiency with operation and troubleshooting of automated liquid handling equipment.
  • Ability to excel in a collaborative, fast paced and dynamic environment • Excellent oral and written communication skills. Proficiency with personal computers, including word processing, spreadsheets, PowerPoint and relevant scientific software.


Nice-to-Have
  • Experience with high content imaging •Experience with writing scripts to automate data processing.


Other Job Details
  • Last Date to Apply: December 31, 2021
  • Eligible for Employee Referral Bonus
  • Eligible for Relocation Package
  • #LI-PFE


Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

#LI-PFE

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