Investigator, Chemical Development
Site Name: USA - Pennsylvania - Upper Providence Posted Date: Nov 10 2021 GSK is seeking a proactive chemist to join Chemical Development at our US R&D Hub located in Upper Providence, PA. Our Chemical Development group supports the small molecule portfolio in GSK Pharma R&D with an inter-disciplinary team of process chemists, chemical engineers, and materials science experts by developing the synthetic routes and associated manufacturing processes that turn those molecules into medicines. Through our network of 86 manufacturing sites, each year we produce nearly 4 billion packs of medicine and we are committed to widening access to our products so that more people may benefit. A successful applicant will have an excellent practical and theoretical understanding of synthetic organic chemistry or a relevant technology and can design and execute high quality, thoughtful experimentation, while making significant contributions both independently and as a member of a team. Key Responsibilities include, but are not limited to: Designing and performing experiments in a laboratory setting to meet project timelines and objectives. Thinking creatively to generate new ideas for new synthetic routes and simplifying process problems. Ensuring that experimental work is communicated effectively at internal R&D meetings. Participating in technology transfer activities as appropriate to our manufacturing partners Pharma Supply Chain (PSC), other parts of R&D, and partner Contract Manufacturing Organizations (CMOs). Authoring or contributing to regulatory submissions, patents, scientific papers and other internal documentation relevant to the role. Complying with applicable Data Integrity, Quality, cGMP and regulatory requirements in all aspects of work. About You As a member of Chemical Development, you will use your chemistry knowledge and expertise to develop new chemistry routes for primary manufacture and contribute to the development and deployment of state-of-the-art processes and technologies to enable the delivery of our medicines. This is a highly practical role where you will be working in the R&D laboratories to generate new synthetic routes and process understanding that underpins the successful scale-up and commercial industrialization of GSK's future manufacturing processes. Your focus will be to combine the information generated in laboratory studies with your strong knowledge of synthetic organic chemistry to develop sustainable pharmaceutical manufacturing routes and processes. As projects advance through development, pilot plant support may also be required across scales, culminating in the transfer of projects to our commercial manufacturing facilities around the globe. The role is highly technical and dynamic as you will be working in a number of multi-disciplinary project teams. You will thrive in this environment if you are able to effectively manage multiple priorities, communicate your recommendations clearly, and enjoy working in teams. Values and Expectations: Has the courage to take on ambitious goals and move forward at pace. Takes accountability by holding self and others to the commitments that have been made. Ability to learn and grow through challenging work and is willing to give and receive constructive feedback as part of an effort to continuously improve. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Ph.D. in Chemistry or equivalent industrial experience Experience in state-of-the art synthetic organic chemistry Scientific experience in chemistry (e.g. publications, patents, or presentations) Experience in independent planning and execution of experiments Experience in independent interpretation of data from experiments and using it to make meaningful conclusions/decisions regarding the direction of future experimentation Preferred Qualifications: If you have the following characteristics, it would be a plus: Excellent problem solving skills Experience in multistep synthesis of complex organic molecules Experience with high throughput experimentation for reaction optimization and process development activities is a plus, but not required. Experience with Design of Experiments (DoE) is a plus, but not a requirement. Experience in implementation of basic kinetic characterization of organic reactions is a plus, but not required. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. 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