Site Name: USA - Pennsylvania - Upper Providence, UK - Hertfordshire - Stevenage Posted Date: Nov 11 2021 Posting End Date: 11/2/2021 The Director, Modalities will be responsible for applying and developing alternative chemical modalities in drug discovery in order to discover life-changing medicines. This role includes oversight of GSK's targeted protein degradation platform as well as other emerging platforms. This individual will be accountable for developing an innovative and strategic vision for investment in alternative small molecule medicine modalities. The role holder will work with members in Medicine Design and other matrix partners to build an end-to-end discovery capability using alternative chemical modalities. The role holder will be responsible for building capabilities, assessing opportunity to establish partnerships with external experts/collaborators, and be responsible for the day-to-day operations of the team. The Director, Modalities will lead a team of 15-20, will report to the Head of Medicinal Chemistry, and sit on the GSK Global Medicinal Chemistry Leadership Team. This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following: Develop the strategic vision for alternative small molecule medicine modalities at GSK including the protein degradation platform (PROTAC). Proactively work across organizational boundaries to drive utilization of alternative small molecule modalities at GSK. Establish partnerships with external experts/key opinion leaders as well as establish collaborations with external partner organizations. Efficiently direct the resource within their team to ensure timely delivery of laboratory objectives. Proactively identify and enable innovative technologies in the areas of alternative small molecule medicine modalities incorporating 'design-first' principles. Work with line and project team members to deliver objectives contributing ideas and fostering a culture of scientific excellence within the Department. Create and maintain high-performing teams that consistently deliver on objectives by actively managing the performance and development of staff though generation of ASMART objectives and conducting regular performance / development conversations. Set direction for their team(s) and lead with vision, integrity, clear communication, and empathy. Routinely undertake 360-degree communication to update on progress against objectives, share information on strategic initiatives and facilitate communication between peers highlighting potential issues. When appropriate, be part of scientific reviews of projects, providing scientific input and strategic recommendations into portfolio assets. Promote GSK's chemistry brand by enabling teams to publish and present their science and ensure that the IP position of their programs are secured in a timely manner. Role model good practice and be fully compliant with safety guidelines and ensure the compliance of their teams, standard operating procedures, and GSK data integrity policies. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: MS & 15 plus years of small molecule drug discovery OR PhD & 10 plus years Documented drug discovery experience and a working knowledge of alternative modality drug discovery Experience in delivery of novel technologies and/or strategies in small molecule drug discovery at the organizational level Experience working with alternative small molecule modalities key opinion leaders & scientific experts Ability to lead from within a matrix team and across the enterprise Experience managing a team Preferred Qualifications: If you have the following characteristics, it would be a plus: Outstanding written and verbal communication skills Demonstrates courage, can be decisive, can make tough decisions, will speak up, and is ambitious and constantly striving to be better. Demonstrates clear accountability, takes ownership, does what she/he says they will do. Demonstrates personal development, is curious, learns every day and supports others in learning. Demonstrates teamwork: creates bigger and better ideas through teamwork and challenging others. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigour and risk Managing individual and team performance. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Implementing change initiatives and leading change. Sustaining energy and well-being, building resilience in teams. Continuously looking for opportunities to learn, build skills and share learning both internally and externally. Developing people and building a talent pipeline. Translating strategy into action - a compelling narrative, motivating others, setting objectives and delegation. Building strong relationships and collaboration, managing trusted stakeholder relationships internally and externally. Budgeting and forecasting, commercial and financial acumen. *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. 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