Scientist, RNA Target Validation

Cambridge, Massachusetts
November 20 2021
Position Type
Full Time
Organization Type
Job Type
Staff Scientist
What You Will Achieve

Pfizer is making significant investment in the creation of novel, first-in-class therapeutics, by combining internal discovery and validation of drug targets with external partnerships to produce clinical drug candidates for the Pfizer pipeline. This position is within Emerging Sciences Biology (ESB) group in Target Sciences (TS). Target Sciences has expertise in human genetics, functional genomics, automated analytic capabilities and data management, and target validation biology. Target Sciences works together within Pfizer broader External Science & Innovation group to deliver a broad and deep pipeline of drug candidates, based on emerging science in the academic world.

The primary responsibility of the newly created Emerging Science Biology team is to play a driving role in addressing the critical task, identified as a gap, of rejuvenating the WRD pipeline with innovative, differentiated First-In-Class/ Only-In-Class programs in the years to come with a particular focus on RNA projects. This will be addressed by generation of strong data packages from target hypotheses derived from academic outreach and initiatives including ITENs, from human genetics, functional genomics and data mining to enable the initiation of new CTI and RU projects.

We are looking for a Scientist at the BS/MS level who will support the development of molecular, biochemical, and cell-based assays for numerous RNA projects. The candidate will be expected to design and conduct experiments and assays to better understand drug targets, molecular pathways, and evaluate drug candidates.

How You Will Achieve It

You will support the development of molecular, biochemical, and cell-based assays to advance our target validated platform. This position will have hands on experience in primary and ideally iPSC derived cells with background in cancer biology, immunology, or neuroscience. The candidate will collaborate closely with other members of Target Sciences in Cambridge, as well as CTI (Centers of Therapeutic Innovation), Research Unit and partner line scientists and academic partners to ensure aggressive project deliverables, goals and timelines are met. The candidate is expected to embrace and embody the entrepreneurial spirit and biotech-like culture, values and goals of Target Sciences and the greater Emerging Science & Innovation organization and contribute to creating an exciting, collaborative, productive, and scientifically rigorous working environment.


  • MS in molecular/cellular biology, biochemistry, or a closely related field with 5 or more years of experience conducting laboratory research.
  • Experience in RNA modality, cell-based assay development for target discovery and validation experiments is highly desirable.
  • Experience in the design, execution, and analysis of cellular, molecular, and/or biochemical assays.
  • Experience with most or all of the following: cell culture, PCR, qPCR, cell-based assays (e.g. cellular cytotoxicity, proliferation, reporter, ligand binding, etc.), RNA, Western blotting, ELISA, MSD, immunocytochemistry.
  • Appropriately maintain experimental data, generate protocols, and reports.
  • Present experimental design, updates, and results to internal audiences.
  • Highly collaborative with a strong desire to make simultaneous contributions to multiple independent projects in a highly matrixed organization.
  • Strong written and oral communication skills.
  • Ability to succeed in a small, interactive, non-traditional drug-discovery environment.
  • Passionate scientist is able to progress programs under required timelines.

  • Industry experience
  • Experience in one or more of the following: immunology, metabolic disease, oncology, or neuroscience
  • Hands on experience in primary cell culture in assay development and assay execution is preferred.

Other Job Details
  • Eligible for Relocation Support

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


Similar jobs

Similar jobs