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Postdoctoral Associate - Cancer Immunotherapy - Synthetic Immunology

Baylor College of Medicine
Houston, Texas
Closing date
Apr 12, 2022

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Life Sciences, Immunology, Cancer Research
Position Type
Full Time
Job Type
Organization Type
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The Heczey Lab believes that the development of the next-generation of cell therapies will be based on in-vivo (inside the body) genetic engineering of cells which can overcome the immune escape mechanisms employed within the tumor microenvironment to safely and effectively cure patients with cancer. The postdoctoral associate will be part of an energetic team within the combined translational laboratories of the Advance Innate Cell Therapy Center of Texas Children's and the Center for Cell and Gene Therapy of Baylor College of Medicine. This position will focus on developing novel strategies to efficiently and specifically engineer lymphocytes in vivo (inside the body) using principles of synthetic viral particle assembly.

Job Duties

  • Design and conduct the experiments related to the project with the help of the mentor and other team members of the Heczey Lab.
  • Redirect effector lymphocytes to eliminate cancer cells with viral and nonviral vectors including CRISPR-Cas9.
  • Evaluate the functional properties of these engineered cells in preclinical models.
  • Engineer and test effector lymphocytes in invitro and cancer bearing animal models.
  • Analyze the data and present the evolving results at weekly laboratory meetings and research seminars of the Center for Cell and Gene Therapy.
  • Record details of the experiments and the findings in electronic laboratory notebook.

Minimum Qualifications

  • Ph.D. in immunology, genetic engineering or related fields.

Preferred Qualifications

  • Great fund of knowledge of tumor immunology principles.
  • Understanding basic genetic engineering techniques (transfection, retroviral / lentiviral transduction, transposition, CRISPR-Cas9).
  • Viral particle assembly.
  • Protein purification.
  • Excellent aseptic cell culture technique.
  • Enthusiasm and a willingness to learn in a fast-pace, collaborative environment.
  • Strong organizational skills, record keeping, and interpersonal communication skills (verbal and written).

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
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