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Sr In Vivo Research Associate

Employer
Spark Therapeutics
Location
Pipersville, Pennsylvania
Salary
Salary not provided
Closing date
Mar 18, 2022

View more

Discipline
Health Sciences, Drug Development
Job Type
Research Scientist
Organization Type
Biotech
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Job Details

The Senior Research Associate will be responsible for overseeing and performing in vivo studies to support the Liver and Discovery therapeutic areas and other Spark therapeutic areas as needed.

  • Perform Liver and Discovery focused in vivo studies that support the Spark pipeline.
  • Perform IV/IP/PO/SC injections in mice and rats, monitor animal health, collect blood samples, perform necropsies and record data.
  • Establish/Maintain mouse breeding colonies.
  • Research and develop new procedures and techniques, and identify equipment needed to support Liver and Discovery programs.
  • Scheduling and adhering to concurrent studies according to the experimental design.
  • Interact with scientists from different therapeutic areas and provide relevant feedback.
  • Optimize current processes and procedures to improve efficiency.
  • Work autonomuously to support group and organizational needs.

Responsibilities

Perform liver in vivo experiments in laboratory animals according to applicable regulations; studies will utilize mice, rats, and other species, as needed

Train and assist technical staff in the performance of in vivo experiments to support Liver and Discovery therapeutic areas.

Responsible for all safety aspects and best practices, and employee training.

Ensure departmental goals and objectives are met and aligned to the broader organizational goals and objectives.

Prioritize and plan projects and workloads, manage resources and personnel scheduling. Write and review animal protocols for IACUC approval

Education and Experience Requirements

  • Required Bachelor’s degree/MS in relevant field and 5-8 years of hands on experience with small rodent models. Equivielent experience is acceptable.
  • Advanced skills on handling, restraining, dosing and performing a variety of procedures on study animals required.
  • Ability to manage large mouse colonies required.
  • Keep accurate records, follow instructions, and comply with company policies.
  • Experience with AAV vectors is a plus.

Key Skills, Abilities, and Competencies

  • Excellent organizational and collaborations skills.
  • Strong writing and verbal communication skills.
  • Prompt and accurate recording of data.

Complexity and Problem Solving

  • Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems; Discuss with supervisor and refer to policies/practices for guidance.
  • Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
  • Exercise judgment within defined procedures and practices to determine appropriate action.

Internal and External Contacts

Quality Assurance, Clinical Operations, Pharm/Tox, Discovery, Assay Validation, R&D Operations, Technical Operations, Regulatory Affairs

The Senior Research Associate will be responsible for overseeing and performing in vivo studies to support the Liver and Discovery therapeutic areas and other Spark therapeutic areas as needed.

  • Perform Liver and Discovery focused in vivo studies that support the Spark pipeline.
  • Perform IV/IP/PO/SC injections in mice and rats, monitor animal health, collect blood samples, perform necropsies and record data.
  • Establish/Maintain mouse breeding colonies.
  • Research and develop new procedures and techniques, and identify equipment needed to support Liver and Discovery programs.
  • Scheduling and adhering to concurrent studies according to the experimental design.
  • Interact with scientists from different therapeutic areas and provide relevant feedback.
  • Optimize current processes and procedures to improve efficiency.
  • Work autonomuously to support group and organizational needs.
Responsibilities

Perform liver in vivo experiments in laboratory animals according to applicable regulations; studies will utilize mice, rats, and other species, as needed

Train and assist technical staff in the performance of in vivo experiments to support Liver and Discovery therapeutic areas.

Responsible for all safety aspects and best practices, and employee training.

Ensure departmental goals and objectives are met and aligned to the broader organizational goals and objectives.

Prioritize and plan projects and workloads, manage resources and personnel scheduling. Write and review animal protocols for IACUC approval

Education and Experience Requirements

  • Required Bachelor’s degree/MS in relevant field and 5-8 years of hands on experience with small rodent models. Equivielent experience is acceptable.
  • Advanced skills on handling, restraining, dosing and performing a variety of procedures on study animals required.
  • Ability to manage large mouse colonies required.
  • Keep accurate records, follow instructions, and comply with company policies.
  • Experience with AAV vectors is a plus.
Key Skills, Abilities, and Competencies

  • Excellent organizational and collaborations skills.
  • Strong writing and verbal communication skills.
  • Prompt and accurate recording of data.
Complexity and Problem Solving

  • Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems; Discuss with supervisor and refer to policies/practices for guidance.
  • Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
  • Exercise judgment within defined procedures and practices to determine appropriate action.
Internal and External Contacts

Quality Assurance, Clinical Operations, Pharm/Tox, Discovery, Assay Validation, R&D Operations, Technical Operations, Regulatory Affairs

Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.


Nearest Major Market: Philadelphia



Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.

Company

At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
Website
Telephone
215-989-1149
Location
3737 Market Street
Suite 1300
Philadelphia
PA
19104
United States
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