Postdoctoral Research Fellow- Department of Infectious Diseases

The Spearman Laboratory seeks a postdoctoral investigator to work on the interaction of HIV with cells of the central nervous system (CNS). The interactions of HIV with microglia and potentially other cells in the CNS are likely to modulate the occurrence of HIV-associated neurocognitive disorders (HAND).  We are studying HIV-infected microglia and developing cerebral organoid models for the study of HIV interactions with and effects on the brain. Our work on the development of iPSC-derived microglia as an HIV infection model was recently published in Retrovirology [PMID 33213476].

The ideal candidate for this position will have a doctoral degree and experience with tissue culture, use of molecular techniques, and the design of creative experiments. Valuable experience would include culturing of induced pluripotent stem cells (iPSCs), microscopic skills including immunofluorescence analysis, and analysis of cell types and activation using transcriptomics. Contact Paul Spearman (Paul.Spearman@cchmc.org)