Research Associate – Taipale Group

Research Associate – Taipale Group

Applications are invited for a Postdoctoral Research Associate position in the University of Cambridge, Department of Biochemistry, central Cambridge, working in the laboratory of Jussi Taipale, Herchel Smith Professor of Biochemistry. The focus of the work in the laboratory is aimed at understanding how DNA sequences determine where and when genes are expressed (see Yin et al., Science 2017; Wei et al. Nature Biotechnology, 2018; Zhu et al., Nature 2018; Jolma et al., Genome Res. 2020; Yan et al., Nature, 2021), and how mutations and inherited sequence variation cause deregulated transcription and tumourigenesis (see Sur et al., Science 2012; Dave et al, eLife 2017).

The group's research will have an impact on both the fundamental understanding of the regulation of gene expression, and on knowledge of the mechanisms that control cell growth during normal development and in pathologies such as cancer. As part of the phased development of the Taipale group in Cambridge, a position is available for a Post-doctoral Research Associate studying basic mechanisms of gene regulation in human normal and tumorigenic cells using a combination of experimental and computational strategies, including high throughput biochemical assays and functional genomics approaches combined with genome engineering.

The main duties will involve designing, performing and analysing genome-scale experiments to understand basic mechanisms of transcription, and the role of gene regulation and cellular signalling pathways in growth regulation and inheritance of cancer risk. The successful candidates should have (or be close to completing) a PhD in one of the following: Genetics, Biochemistry, Systems Biology, Computational Biology, Medicine or a related field. Applicants with experience and/or interest in developing their skills in both experimental and computational approaches, who have (co)first author publications or work completed for publication would be preferred. Applicants interested in the above research area and/or interested in developing a novel research direction will be considered.

The duration of the appointment is negotiable. The selection process will be conducted in late 2021 and the post is available immediately thereafter. The funds for this post are available for 24 months in the first instance.

Informal enquires can be made by contacting Dr Jussi Taipale, email: ajt208sec@bioc.cam.ac.uk; further information on the Taipale lab can be obtained at https://www.taipalelabs.org/ and https://www.bioc.cam.ac.uk/research/taipale

Fixed-term: The funds for this post are available for 24 months in the first instance.

To apply for this position please visit: https://www.jobs.cam.ac.uk/job/32251/