Histologist
- Employer
- Spark Therapeutics
- Location
- Pennsylvania
- Salary
- Salary not provided
- Closing date
- Dec 10, 2021
View more
- Discipline
- Life Sciences, Biotechnology
- Organization Type
- All Industry, Biotech
Job Details
- All phases of tissue preparation, including fresh or in-process specimens (paraffin and frozen)
- Routine paraffin and cryo embedding and sectioning, H&E (Hematoxylin & Eosin) staining, special stains technique (histochemistry), immunohistochemistry, immunofluorescence, and in situ hybridization are required.
- Intake and examineof tissues, applying understanding of gross anatomy and study purpose to determine and dissect appropriate representative samples for histology testing and pathology analysis.
- Specimen preparation that requires a basic understanding of tissue structure, as well as an understanding of chemistry and physics; and how tissues react under process conditions, including decalcification, rehydration, grossing, fixation, embedding, microtomy, routine staining, special stains (histochemistry), and immunohistochemistry.
- Maintainenance of reagent and consumable stocks and contributes to their curation
- Summarize findings (PowerPoint presentation, research reports etc.) and communicate to peers and management and other business groups as projects evolve
- Hands-on Tissue processing, staining and image acquisition
- Participate in study investigations develop histology-based biomarker assays
- Review and revise SOPs and/or work instructions
- Communicate findings and provide presentations
- Maintain equipment and records
- Maintain laboratory safety procedures and compliance records
- Prepare laboratory reagents/materials
- B.S./M.S. in relevant field with 3+ years pre-clinical histology experience; having HT/HTL (ASCP) certification would be preferred
- Has expertise in histology-based biomarker assays
- Skilled in performing and troubleshooting singleplex and multiplex IHC, IF, and ISH assays.
- Excellent interpersonal and communication skills as well as the ability to work effectively as part of a cross-functional team
- Strong organizational skills.
- Excellent writing and verbal communication skills.
- Independently motivated, detail oriented and good problem solving ability.
- Ability to multitask.
- Ability to analyze and troubleshoot experiments.
- Demonstrate problem solving skills of technical issues; develop solutions to a variety of simple to moderately complex problems; Discuss with supervisor and refer to policies/practices for guidance.
- Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
- Exercise judgment within defined procedures and practices to determine appropriate action.
Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.
Join the Spark Team
We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.
We don't follow footsteps. We create the path.
Company
At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.
Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.
Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.
- Website
- http://sparktx.com/
Get job alerts
Create a job alert and receive personalized job recommendations straight to your inbox.
Create alert