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Senior Principal Scientist, Chemoproteomics

South San Francisco, California
Closing date
Jan 14, 2022

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Life Sciences, Biochemistry, Proteomics
Position Type
Full Time
Organization Type
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Join a Team that Lives to Improve Lives People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what's possible. And a focus on doing the day-to-day work that makes great science happen.

The following opportunity exists in South San Francisco, CA:

Senior Principal Scientist, Chemoproteomics


The Microchemistry, Proteomics, Lipidomics (MPL) and Next Generation Sequencing (NGS) Department is seeking an experienced Senior/Principal Scientist with a record of high impact research involving chemoproteomics to join the group. The successful individual will lead Chemoproteomics efforts within MPL+NGS and drive the development and application of cutting-edge proteomic tools.

Chemoproteomics approaches are vital to discovering and understanding drug interactions with the proteome in its native environment, and in this role you will be leading and developing chemoproteomics research as a principal investigator. You will serve as a technology leader in a highly interdepartmental collaborative environment at the interface of small molecule research and proteomics, with the goal to make an impact on our drug pipeline. You will also have the opportunity to establish external collaborations that augment our internal research activities. Areas of research include target identification, lead finding and lead optimization relating to discovery and pipeline projects.

Advances in mass spectrometry proteomics and associated areas have revolutionized the study of cellular proteins and motivated in depth molecular characterization of normal human physiology and disease biology. The MPL group is a world leader in the application of technologies, including mass spectrometry and plate-based proteomic methods, to elucidate new models of the molecular mechanisms of disease and the development of novel therapeutics. As is true across Genentech, research in MPL is fast paced and highly collaborative, drawing on the expertise of some of the world's leading experts in biochemistry, technology, computational biology and disease.

Who You Are

• PhD in Chemistry, Biochemistry or related field, with 5-10 years of experience, including postdoc or industrial experience in chemical proteomics.

• Experience managing direct reports (Post-docs, Jr. Scientists, etc)

• Track record of independent research to conceive ideas, develop studies and derive conclusions as demonstrated by high profile publication.

• Extensive experience in mass spec-based chemoproteomics techniques and data analysis.

• Experience in leading activity-based protein profiling and collaborative chemoproteomics efforts.

• Experience with new chemical modalities is a plus.

• Strong communication & interpersonal skills.

• Strong computational skills and a basic understanding of at least one programming language.

• Ability to mentor colleagues to enable their scientific potential.

Who We Are?

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work. The next step is yours.

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Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page. If you are in need of an accommodation due to a disability to assist with submitting your application or at any point during the hiring process, please email


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