Postdoctoral Position

Pittston, Pennsylvania (US)
Salary commensurate with experience.
November 12 2021
Position Type
Full Time
Organization Type
Job Type

NIH-funded post-doctoral position available for enthusiastic, driven, hard-working individual to conduct research into the mechanisms that impact T cell function and immune regulation in Dr. Dario Vignali’ s laboratories at the University of Pittsburgh and UPMC Hillman Cancer Center. 

With the support of a recently renewed NIH P01, the successful applicant will investigate the mechanisms that control CD4+ T cell exhaustion in mouse models of cancer. This project will emphasize use of, system biology approaches, sophisticated immunological techniques (scRNAseq and CRISPR) and novel mouse model systems. The successful applicant may also be involved in the development of novel biologics for proof-of-concept therapeutic experiments in mouse models.

The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EOE, including disability/vets.

This position will focus on gaining a mechanistic understanding and therapeutic development of pathways and processes under investigation.  Candidates should have a PhD or MD/PhD (no more than 2 years post second degree), a solid understanding of basic immunology, and ideally practical experience with mouse models of disease.  Training grant eligible candidates (US citizens and green card holders) are strongly encouraged to apply.  Candidates will also develop skills in wide variety of techniques, such as mouse models of cancer, analysis of human tumor samples, immune function assays, flow cytometry, single molecule microscopy techniques, a variety of signaling techniques, system biology approaches (scRNAseq and CRISPR), several multispectral imaging approaches, molecular biology techniques, etc.  The candidate will also gain considerable experience writing manuscripts, reviews and grants along with oral presentations. Additional duties will include mouse colony management, training of undergraduate and graduate students, participation in department activities, presentations at lab, local and national meetings and any other assignments that the PI may request.  Additional information about the Vignali Lab can be found at:

Twitter: @Vignali_Lab


Interested candidates should send (a) a cover letter noting the position of interest listed above, a brief description of research interests and future career goals, (b) CV, and (c) contact information for three references to Barb Beatty (E-mail:

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