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Research Technician II – Bassler Lab, Princeton University

Princeton, New Jersey
Salary based on experience
Closing date
Dec 11, 2021

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Life Sciences, Cell Biology, Genomics
Position Type
Full Time
Job Type
Organization Type
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We are currently looking for a highly motivated Research Technician to work Dr. Bonnie Bassler’s lab at Princeton University. The Bassler Lab aims to understand how bacteria communicate and orchestrate group behaviors, including virulence and biofilm formation. This process, known as quorum sensing, relies on chemical “words” and enables populations of bacteria to regulate gene expression, and therefore behavior, on a community-wide scale. More information can be found on their website.


The Bassler Lab is highly collaborative and values the input and contribution of all lab members. This position will directly support the science, contribute to papers, and thrive in a supportive, creative, and learning-focused environment. 


We are ideally targeting candidates seeking a long-term, stable position who are passionate about contributing to the lab’s full research portfolio.


Principal Responsibilities:


  • Work with the P.I. and other lab members to carry out various molecular, genetic, biochemical, and pharmacological studies of quorum-sensing pathways and their inhibition, protein function, and gene regulation


  • Work efficiently, primarily collaboratively, with postdoctoral fellows and graduate students in experiments focused on bacteria, including employing the following:


  • Prepare and analyze purified proteins for biochemical studies, cloning, PCR, cell culture, protein expression, and standard basic molecular biology techniques


  • Assay, evaluate, and characterize novel small molecule candidates as anti-microbials


  • May perform more advanced molecular biology procedures such as the design and synthesis of custom plasmid DNA vectors or gene expression profiling using QRT and QPCR protocols.


  • Identify and apply improvements to shared resource procedures and protocols.


  • Perform light administrative responsibilities related to lab safety, ordering, and databases.


  • Assist with other light support duties relating to lab management and operations as required


  • Participate in laboratory group meetings and read literature applicable to the research area




  • Bachelor’s degree with course work in biochemistry, genetics, and molecular biology is required


  • At least 2 years of hands-on, post-graduate experience working in a research lab, with experience in:


  • Basic molecular biology techniques, such as cloning and PCR,  standard biochemical assays, such as protein purification, western blotting, and enzyme assays, and standard scientific computer use


  • Previous experience with any of the following standard molecular biological techniques is preferred but not necessary:


  • Bacterial transformations, reporter assays, bacterial genetics, biochemistry, microtiter dish-based assays; comfort with data analysis; ordering of supplies


Skills and abilities:


  • Flexibility to adapt to the science and research needs of the lab and its members


  • Excellent listening, communication, and collaboration skills


  • Ability to work as a team member and engage in collaborative studies as well as ability to work independently


  • Able to learn tasks with instruction, and to use experience to perform new techniques


  • Actively seeks opportunities to increase skills and expertise


Physical Requirements


Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Work may involve possible exposure to malodorous vapors, low dose radiation, contamination by toxic chemicals and acids and presence of carcinogenic substances. 


Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.


Please Note:


This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however.  Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.


HHMI is an Equal Opportunity Employer

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