Research Fellow

Research Fellow – Lindsley Laboratory
Dana Farber Cancer Institute
 

A full-time post-doctoral fellowship position is available in the laboratory of Dr. Coleman Lindsley (https://lindsleylab.dana-farber.org/) at the Dana-Farber Cancer Institute (DFCI) and Harvard Medical School. We use interdisciplinary approaches at the interface of genomics and molecular biology to understand the mechanisms of human disease, with the aim of translating these insights into novel therapies for patients with cancer. The ideal candidate is collegial, creative, and highly motivated, with a strong record of productivity during graduate training. The position will involve the study of hematologic malignancies, and projects will integrate analysis of primary human samples and engineered mouse models. Technical skills involving tissue culture, flow cytometry, and standard molecular and cell biology techniques are highly desirable. Prior experience with small animal models would be an advantage but is not required. An MD, PhD, or MD/PhD is required.

Projects will be tailored to a candidate’s experience, interests, and goals, within the following areas of laboratory focus:

• Germline leukemia predisposition syndromes (pathogenesis, transformation, novel surveillance and therapeutic strategies). Anticipated projects will focus on Shwachman-Diamond syndrome and telomere biology disorders.
• Bone marrow transplantation (understanding donor/disease/recipient factors that drive relapse and toxicity). Anticipated projects will focus on how clonal hematopoiesis in donors impacts recipient outcomes, and how recipient genetic characteristics influence graft-versus-host disease severity.
• Genetic pathways of disease progression (gene-gene interactions, epigenetics, novel therapeutic vulnerabilities). Anticipated projects will focus on Polycomb-repressive complex 1.1 and RNA splicing.

The laboratory is situated in the Division of Hematologic Neoplasia at DFCI, within a vibrant community of translational and basic research that includes Harvard Medical School, the Broad Institute of MIT, Brigham and Women’s Hospital, and Boston Children’s Hospital.

Requirements

The responsibilities of this full-time position will also include some general lab duties as outlined below.

• Design and perform experiments both individually and collaboratively.
• Prioritize research plan.
• Provide advice and training for junior members of the lab.
• Work on problems of diverse scope.
• Develop, modify, and improve standard lab operating procedures.
• Select methods and techniques for obtaining solutions.
• Analyze and present data both informally and formally.
• Write career development grants.
• Prepare manuscripts.
• Expected to provide guidance and training to lab technicians/technical research assistants and other junior lab members on established processes and procedures.

Qualifications

The ideal addition to the Lindsley Laboratory will:

• Be kind and collegial
• Enjoy working in a team environment with a wide variety of faculty and staff
• Be an innovative, forward-thinking critical scientist
• Have excellent communication skills (written and verbal)
• Possess outstanding planning, organizational, multi-tasking skills
• Those with relevant and/or complimentary expertise, including but not limited to the following skills are encouraged to apply:
  • Tissue culture
  • Flow cytometry
  • Standard molecular and cell biology techniques
  • Small animal (mouse) models
  • Bioinformatics 

For more information and to apply, please visit: https://careers.dana-farber.org/research_fellow_lindsley_lab

About Dana Farber:
Located in Boston and the surrounding communities, DFCI brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.