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Formulation Research Associate

Spark Therapeutics
Philadelphia, Pennsylvania
Salary not provided
Closing date
Dec 14, 2021

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Job Details

The Research Associate is a member of the Discovery Research Group within the Translational Research Department and will support laboratory research activities towards the development and testing of novel gene therapy products. He/she will be responsible for:

• Routinely formulate and characterize nanoparticle-based formulations (e.g. liposomes, lipid nanoparticles) at varying scales.

• Optimize existing formulation methods and analytical techniques and generate standard operating procedures (SOPs) and test method documents

• Conduct experiments, independently and in collaboration with colleagues in support of project goals

• Analysis and accurate documentation of assay results in an electronic lab notebook, technical documents, and other reporting formats.


Describe the essential daily job functions and include % of time spent on each.

Job Function and Description

Plan, prepare, and perform experiments on the bench to support Discovery Research Group projects. Assist technical staff in the performance of laboratory experiments as needed.

Prepare sample analysis reports and accurately document work in electronic lab notebook

Participate in group meetings and scientific discussions/troubleshooting.

Education and Experience Requirements

Include educational requirements or equivalency, required years and type(s) or experience, and necessary licenses or certificates.

• BA/BS in chemistry, engineering, pharmaceutical sciences, or biological sciences required. Master’s degree preferred

• Generally has 3-5 years of relevant experience

• Familiarity with various analytical methods including, but not limited to HPLC, DLS, zeta potential, and encapsulation efficiency

Key Skills, Abilities, and Competencies

• Experience in general and advanced nanoparticle formulation techniques

• Experience with different characterization methods such as HPLC, DLS, zeta potential, and encapsulation efficiency

• Proven ability to work independently in hands-on laboratory setting, self-motivated to learn and develop new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies.

• Familiarity of Electronic Lab Notebook (ELN) and Laboratory Information Management Systems (LIMS) a plus.

• Familiar with computer software commonly used in bio/pharma industries.

• Strong organizational skills.

• Excellent communication skills (both oral and written).

• Works with colleagues as a team player.

Complexity and Problem Solving

• Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems; Discuss with supervisor and refer to policies/practices for guidance.

• Ability to work independently after initial training as well as being part of a team

• Self-motivated, flexible, and willing to adapt to meet team goals.

• Keep accurate records, follow instructions, and comply with company policies.

• Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.

• Exercise judgment within defined procedures and practices to determine appropriate action.

Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.

Nearest Major Market: Philadelphia

Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.


At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
3737 Market Street
Suite 1300
United States
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