Postdoctoral Fellow - Protein Engineering for Immunotherapy

Duarte, California
July 15 2021
Position Type
Full Time
Organization Type
About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

The Williams lab is looking for a highly motivated Postdoctoral Fellow to advance the meditope technology platform to create novel ADCs and tumor-activated biologics for immunotherapy. The successful candidate will be highly skilled in protein production (E coli and mammalian cells), protein purification using various chromatographic methods, and characterization (HPLC, SPR, ITC, Mass spec), and cell-based assays. Experience in animal tumor models is a plus. The ideal candidate will have a solid publication record, excellent communication skills (written and verbal) and outstanding record keeping. The primary goal is to translate these efforts into the clinic to cure cancer. Critically, City of Hope has all the infrastructure to make this happen including three GMP facilities.

Basic education, experience and skills required for consideration:
  • PhD in chemistry, biochemistry, protein chemistry, biochemical engineering or related field with 1 to 3 years of postdoctoral experience
  • Experience with protein production and purification
  • Fully versed in protein purification methods (HPLC, SPR, ITC, Mass Spec)
  • Excellent written and verbal communication skills
  • Good problem-solving skills
  • Ability to conduct independent research
  • Ability to supervise others and work effectively in a team

Additional Information:

City of Hope is a world leader in translational medicine, including synthesis of first synthetic gene, humanization of monoclonal antibodies and pioneering work in CAR T cells. These discoveries have led to some of the most important therapeutics in world including recombinant insulin for maintenance of type 2 diabetes and Rituxan, Herceptin, Avastin, etc. for the treatment of cancer. Building off these successes, City of Hope houses three FDA approved GMP facilities along with its 27 core facilities to rapidly advance discoveries.
  • For more information about Dr. Williams' research, please click here .
  • Please note, this is one of multiple openings available in Dr. Williams' lab.

To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


  • Posting Date: Oct 25, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job

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