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In Vivo Research Lead - Ocular

Spark Therapeutics
Pipersville, Pennsylvania
Salary not provided
Closing date
Dec 17, 2021

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Health Sciences, Drug Development
Job Type
Research Scientist
Organization Type
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Job Details

*Please Note: This position will have responsibilities at both the Rowan/Camden facility as well as the Pipersville location.**

The Ocular In Vivo Lead will be responsible for scheduling, training and performing In Vivo studies to support the Ocular therapeutic area and other therapeutic areas of the Non-Clinical department, if needed.

Additional responsabilities include but are not limited to:

  • Oversee Ocular In Vivo studies.
  • Mentor and train In Vivo staff in Ocular procedures.
  • Schedule and follow multiple concurrent studies according to the experimental design.
  • Perform In Vivo studies, as needed.
  • Review and ensure compliance with IACUC Protocols/amendments and EHS procedures.
  • Perform IV/IP/SC/ Intravitreal/Subretinal injections in mice, monitor animal health, collect blood samples, perform necropsies.
  • Perform Electroretinography, OCT and OKR monitoring in injected animals.
  • Maintain mouse breeding colonies.
  • Perform and oversee technical procedures for animal studies.
  • Ensure accurate data recording.
  • Animal, general supplies and reagent ordering.
  • Interact with Ocular scientists and In Vivo Lead and provide constant feedback.
  • Work cross-functionally with CNS and Liver and discovery teams and provide support to other R&D in vivo needs.


% of Time

Job Function and Description


Oversee scheduling and execution of Ocular procedures from team members. Assure IACUC compliance, proper procedure documentation and maintain accurate record of procedures and provide results/comments to study directors.


Perform and train team members in In Vivo techniques and animal monitoring according to applicable regulations in support of the Ocular team and other therapeutic areas.


Provide work assignments to the team on a regular basis. Review and approve the work performed by other team members. Ensure work is done in a compliant manner.


  • Manage performance. Ensure every team member knows what is expected of them, what it takes to be successful, and how they are progressing. Provide team members with continuous and on-going performance feedback. Hold everyone accountable to achieve results while demonstrating the Spark Values. Help team members understand how their work contributes to the overall success of Spark by periodically reviewing individual objectives to ensure alignment to corporate and functional objectives, making adjustments if priorities have shifted.
  • Develop team members. Help employees effectively assimilate to Spark and continually grow through challenging experiences so they can realize their full potential. Understand your employee’s goals, strengths and motivators. Partner with your employees to identify areas for development, conduct coaching conversations regularly and provide guidance on ways to develop through on the job experiential learning, social networks and development opportunities.
  • Foster Spark’s Culture, Mission, Vision, and Values: Lead by example. Create an environment where team members thrive in our Culture by living our truths, always in compliance with applicable laws and regulations. Emphasize to employees that “how” they achieve performance objectives is just as important as “what” they accomplish.
Education and Experience Requirements

  • Bachelor’s degree in relevant field required; Master’s degree, Ph.D. preferred.
  • Generally has 5+ years of hands on relevant experience with rodents and managing people.
  • Advanced skills on handling, restraining, dosing (IP, IM, and IV) and performing a variety of procedures on study animals required.
  • Experience with managing transgenic mouse colonies required.
  • Keep accurate records, follow instructions and comply with company policies.
  • Ability to manage large mouse colonies required.
  • Excellent organizational, communication and collaboration skills.
  • Keep accurate records, follow instructions and comply with company policies.
  • Experience with Gene Therapy is a plus.
  • Previous experience in team leading is preferred.
  • Experience with IACUC is a plus.
Key Skills, Abilities, and Competencies

  • Strong organizational skills.
  • Detail oriented
  • Demonstrated ability to effectively manage multiple programs. Excellent record keeping.
  • Excellent writing and verbal communication skills.
  • Experience in training and supervising preferred.
  • Experience in managing and working cross-functionally.

Complexity and Problem Solving

  • Demonstrate independent problem-solving skills of technical issues.
  • Develop solutions to a variety of moderate to complex problems; Discuss with supervisor and refer to policies/practices for guidance.
  • Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark.
  • Exercise judgment within defined procedures and practices to determine appropriate action.
Internal and External Contacts

  • Ocular In Vivo Lead is accountable to the In Vivo Lead and serves as a key collaborator and peer to the In Vivo Therapeutic area Research teams.
  • Will be in contact with Quality Assurance, Non-Clinical Operations, Clinical Operations, Pharm/Tox, Discovery, Assay Validation, R&D Operations, Technical Operations, Regulatory Affairs


Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.

Nearest Major Market: Philadelphia

Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.


At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
3737 Market Street
Suite 1300
United States
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