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CNS Research Associate

Employer
Spark Therapeutics
Location
Philadelphia, Pennsylvania
Salary
Salary not provided
Closing date
Dec 23, 2021

View more

Discipline
Health Sciences, Drug Development
Job Type
Research Scientist
Organization Type
Biotech
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Job Details

Primary Duties

  • Conduct experiments in the area of neurodegeneration, neuron cell biology, and histology (specimen preparation, processing, acquisition, and analysis).
  • Provide technical support in running ex-vivo pre-clinical experiments to evaluate treatment efficacy and safety.
  • Participate in key aspects of general lab management and organization (e.g., managing histology related reagents and histology samples inventories, and support team members with dayto-day activities).

Responsibilities

% of Time Job Function and Description

80%

Collaborate to perform experiments on the bench in support of the CNS research projects, including new assay development and troubleshooting. Data analysis and an extensive literature review

20%

Oversee and/or provide technical support of specialized equipment as needed.

Manage CNS research samples and materials.

Manage reagents inventories.

Education and Experience Requirements

  • Bachelor’s degree required, Masters in a relevant field preferred (Neuroscience, Molecular Biology, Cell Biology, Gene Therapy).
  • Minimum of 3 years of relevant experience as Lab Assistant, Histology Technician or equivalent.
  • Experience in AAV or gene therapy preferred, but not essential.
  • Adept at conducting routine testing and limited troubleshooting of multiple methods.
  • At least one year hands on experience in preparation and processing/staining of histological specimen (immunohistochemistry)
  • Experience in RNAscope preferred, but not essential.
  • Track record in microscopy and image acquisition and analysis
  • At least one year hands on experience in general molecular biology (DNA and RNA isolation, PCR, RT-PCR, and Q-PCR), protein biochemistry and cell biological approaches.
  • Ordering and receiving lab materials.
  • Responsible and reliable in managing samples and running the experiments.

Key Skills, Abilities, and Competencies

  • Ability to build trust through operating with transparency and creating an open and positive environment.
  • Ability to analyze and troubleshoot experiments.
  • Ability to manage competing priorities in a fast-paced environment.
  • Strong interpersonal skills demonstrated by the ability to lead and gain the assistance and cooperation of others in a team endeavor.
  • Strong organizational skills and communication skills.
  • Independently motivated and exceptionally detail oriented.
  • Ability to learn new techniques and work independently after training.

Nearest Major Market: Philadelphia



Join the Spark Team

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable - until now.

We don't follow footsteps. We create the path.

Company

At Spark Therapeutics, a fully integrated, commercial company committed to discovering, developing and delivering gene therapies, we challenge the inevitability of genetic diseases, including blindness, hemophilia, lysosomal storage disorders and neurodegenerative diseases.

Founded in March 2013 as a result of the technology and know-how accumulated over two decades at Children’s Hospital of Philadelphia (CHOP), our investigational therapies have the potential to provide long-lasting effects, dramatically and positively changing the lives of patients with conditions where no, or only palliative, therapies exist. Greater understanding of the human genome and genetic abnormalities have allowed our scientists to tailor investigational therapies to patients suffering from very specific genetic diseases. This approach holds great promise in developing effective treatments to a host of inherited diseases. Our initial focus is on treating orphan diseases.

Headquartered in dynamic Philadelphia, we are a diverse, experienced team united in our goal to break down barriers for people and families affected by genetic diseases. As our name suggests, our investigational, one-time therapies are designed to spark healthy biology, and deliver potentially life-altering transformation for people and families affected by genetic disease. Spark is a member of the Roche Group.

Find Us
Website
Telephone
215-989-1149
Location
3737 Market Street
Suite 1300
Philadelphia
PA
19104
United States
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