Site Name: USA - Pennsylvania - Upper Providence Posted Date: Oct 2 2021 The Novel Human Genetics Research Unit (NHG RU) at GSK comprises a multidisciplinary team that utilizes deep scientific knowledge and technical capabilities to identify and validate novel therapeutic targets with genetic association to diseases and undertake drug discovery efforts from early stage discovery through to phase 1 clinical trials. We are seeking to hire a highly motivated scientist to fill a Senior Scientist position in the Novel Human Genetics Research Unit in R&D. The successful candidate will be part of a multidisciplinary team to design and execution of genetic studies in disease-relevant cellular systems for target validation studies. Specifically, the successful candidate will perform experiments interrogating genes/pathways in physiologically- or disease-relevant cellular models (including iPS-derived cells and primary cells) via genetic or chemical means and will measure the impact via phenotypic assays. The scientist will have the opportunity to work on targets and pathways relevant to a variety of human diseases and therapeutic areas. Job functions: •Maintain cell culture (cell lines / human primary cells) to support assay development. •Utilize various transfection/transduction methods to knockdwon or overexpression target genes in cell lines / primary cells. •Conduct experiments directed to investigate the biological effects of target genes. •Perform detections of biomarker changes using various assay methods, such as ELISA, Western, imaging, RT-PCR. •Analyze and summarize experimental data using a variety of laboratory instrumentation and computer softwares. •Maintain accurate laboratory notebooks according to company guidelines. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: •BS or MS in Biological Sciences required with laboratory experience in molecular biology and cell biology. •Candidate is expected to have experience in sterile cell culture and gene expression (knockdown and overexpression) techniques. •Experience in cell-based assays (e.g. immune-sandwich, reporter gene etc.) and/or biochemical assays. •Ability to execute experiment independently and work collaboratively with colleagues. •Candidate must be able to do independent literature research, analyze, summarize and interpret experimental data and maintain records according to company policy. •Candidate must have the ability to cooperate with others both to accomplish scientific goals and to perform general maintenance duties. Preferred Qualifications: If you have the following characteristics, it would be a plus: PhD Experience with cell imaging . Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. *This is a job description to aide in the job posting, but does not include all job evaluation details. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.