Senior Scientist

Site Name: USA - Pennsylvania - Upper Providence Posted Date: Oct 2 2021 The Novel Human Genetics Research Unit (NHG RU) at GSK comprises a multidisciplinary team that utilizes deep scientific knowledge and technical capabilities to identify and validate novel therapeutic targets with genetic association to diseases and undertake drug discovery efforts from early stage discovery through to phase 1 clinical trials. We are seeking to hire a highly motivated scientist to fill a Senior Scientist position in the Novel Human Genetics Research Unit in R&D. The successful candidate will be part of a multidisciplinary team to design and execution of genetic studies in disease-relevant cellular systems for target validation studies. Specifically, the successful candidate will perform experiments interrogating genes/pathways in physiologically- or disease-relevant cellular models (including iPS-derived cells and primary cells) via genetic or chemical means and will measure the impact via phenotypic assays. The scientist will have the opportunity to work on targets and pathways relevant to a variety of human diseases and therapeutic areas. Job functions: •Maintain cell culture (cell lines / human primary cells) to support assay development. •Utilize various transfection/transduction methods to knockdwon or overexpression target genes in cell lines / primary cells. •Conduct experiments directed to investigate the biological effects of target genes. •Perform detections of biomarker changes using various assay methods, such as ELISA, Western, imaging, RT-PCR. •Analyze and summarize experimental data using a variety of laboratory instrumentation and computer softwares. •Maintain accurate laboratory notebooks according to company guidelines. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: •BS or MS in Biological Sciences required with laboratory experience in molecular biology and cell biology. •Candidate is expected to have experience in sterile cell culture and gene expression (knockdown and overexpression) techniques. •Experience in cell-based assays (e.g. immune-sandwich, reporter gene etc.) and/or biochemical assays. •Ability to execute experiment independently and work collaboratively with colleagues. •Candidate must be able to do independent literature research, analyze, summarize and interpret experimental data and maintain records according to company policy. •Candidate must have the ability to cooperate with others both to accomplish scientific goals and to perform general maintenance duties. Preferred Qualifications: If you have the following characteristics, it would be a plus: PhD Experience with cell imaging . Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. *This is a job description to aide in the job posting, but does not include all job evaluation details. 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