Research Assistant II - Genetics (Molecular or Quantitative Biology)

Location
Houston, Texas
Salary
Competitive
Posted
October 25 2021
Ref
144102
Discipline
Health Sciences
Organization Type
Healthcare/Hospital
The Genetics department is a basic science department located in the George and Cynthia Mitchell Basic Sciences Research Building at the world-renowned University of Texas MD Anderson Cancer Center in the heart of the Texas Medical Center. The focus is on advancing knowledge of the molecular genetic mechanisms that regulate normal and abnormal cellular processes.

Cancer cells accumulate detrimental genetic mutations that perturb the function of important proteins they express. Our lab investigates how protein-folding chaperones (a specialized suite of proteins that help mutant proteins to fold and function within cells) influence the accumulation and phenotypic manifestations of cancer mutations. The ultimate goal of this work is to identify new targeting strategies for precision cancer medicine. We are looking for a Research Assistant II, who will make significant contributions towards achieving this goal.

The Research Assistant II provides responsible technical assistance in support of research projects by completing assignments requiring a basic knowledge of fundamental techniques and practices related to a particular field of academics or research.

Key Functions
  • Assists principal investigator with scientific research projects focused on understanding the impact of protein-folding chaperones on the accumulation of genetic variation and how they relate to evolution and cell function.
  • Functions, under supervision, in the design and initiation of research experiments. These experiments include, but are not limited to, genetic engineering of yeast and cancer cell lines, assessment of cellular drug tolerance in culture, chemical genetics, cloning plasmid DNA libraries for high-throughput assays, RT-PCR, Western blotting, immunohistochemistry, protein purification, proteomics, metabolomics, and other multi-omics approaches.
  • Performs bioinformatic analyses of next-generation DNA and RNA sequencing data to infer expression, gene copy number variation and perform de novo genome assembly.
  • Executes data integration pipelines and statistical analyses.
  • Assists in training and research work activity for assigned laboratory and research personnel.
  • Supervises general laboratory management including the assembly and use of laboratory equipment and implements safety procedures.
  • Assists with basic laboratory techniques and in preparation of media solutions, buffers and reagents.
  • Reads literature and confers with superiors regarding new procedures and modifies them according to the needs of the project.
  • Other duties as assigned.


Education

Required: Bachelor's degree with major course works in one of the basic sciences.

Preferred: Master's degree with major course works in one of the basic sciences.

Experience

Required: Two years experience in scientific or experimental research work. No experience required with preferred degree.

Preferred: Previous training in molecular and/or quantitative biology is preferred.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html