GSK

Senior Scientist

Employer
GSK
Location
Collegeville, PA
Salary
Competitive
Posted
October 25 2021
Ref
308263
Organization Type
Pharma
Job Type
Senior Scientist
Site Name: USA - Pennsylvania - Upper Providence Posted Date: Oct 25 2021 GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to support our mission to improve the quality of human life by enabling people to do more, feel better and live longer. An exciting opportunity has arisen for a highly motivated protein biochemist with a passion for protein technology, to join the department of Protein, Cellular, and Structural Sciences (PCSS) at GSK's facility in Upper Providence, Pennsylvania. The primary responsibility of the department is to design, generate and validate biological reagents for discovery activities across all of GSK's therapeutic modalities. The department also provides the structural and mechanistic understanding of drug target, molecular recognition and mode of action to deliver the best molecule. The successful candidate will be responsible for the conceptual design and generation of protein reagents for use in GSK's small molecule drug discovery platforms enabling mechanistic studies, assay development, protein generation, or structural/biophysical workstreams. This scientist will have the opportunity to work on targets in multiple therapeutic areas as well as with automation/ high-throughput workflows. Experience carrying out automated methods for construct generation, protein expression and purification would be desirable. Automation, data management and in silico protein design skills are also desirable. The appointee will be capable of good experimental record-keeping and will have excellent written and oral communication skills. You will be expected to attend project meetings and contribute to project teams in a collaborative manner. An ability to work towards agreed timelines and effectively organise their work will be considered a key asset of the successful applicant. Title and salary will be commensurate with experience. Key Responsibilities include, but are not limited to: Responsible for protein expression and purification platforms for various expression systems and development of new platforms Management of the processed reagents and data Work in a matrix team environment to enable optimal delivery of project and department objectives to the highest possible scientific standard Independently execute laboratory experiments and/or advanced data analysis, integration and interpretation with an emphasis on providing appropriate context for data and experiments in the progress of programs and/or platforms Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety training and practice Why you? Basic Qualifications: Bachelor's degree in a life sciences discipline (e.g. Biochemistry, Molecular biology, Cell Biology, Microbiology) with 5+ years of relevant laboratory experience, or a Master's with 2+ years of relevant laboratory experience. 2 year experiences in recombinant protein expression using microbial hosts, and cell free systems 2 year experiences for protein expression and purification platforms for various expression systems and development of new platforms 2 year experiences in protein QC using various biochemical and biophysical tools. Preferred Qualifications: Qualified candidates should have strong track-record in either one or more of the following disciplines: Protein Expression/Purification, Protein Design If you have the following characteristics, it would be a plus: Understanding multiple expression systems including bacterial, mammalian, baculovirus and cell free systems. Experience in protein purification-affinity chromatography, SEC and IEX Advanced data analysis experience, e.g. Excel or Spotfire. Experience in assay development and protein engineering is desirable. Experience in LIMS Practical knowledge and understanding of automation Excellent organizational, analytical and presentation skills Practical knowledge of gene synthesis, library construct design, and NGS Ability to plan and execute multiple tasks concurrently and evaluate multiple scientific strategies in parallel where appropriate Demonstrated strengths in high performance behaviors, such as building relationships, flexible thinking, and enabling/driving change. Ability to support reagent production timeline goals, generating fit-for-purpose reagents for assays, x-ray crystallography, cryo-EM, protein NMR, biophysics, and enzymology Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. At GSK, we're a company with a special purpose, to help people do more feel better and live longer. Realising our purpose starts with us. When we feel at our best, we perform at our best. When you set out on your adventure at GSK, we make a deal. You commit to living GSK's values and expectations and performing against our Innovation, Performance and Trust priorities. And in return, GSK commits to providing the right environment for you to thrive. Put simply, it's about you being motivated to do your best work, in a place where you can be you, feel good and keep growing. Together we build an environment where we can all thrive and focus on what matters most to each of us. It is only through the energy, dedication, drive and passion of all of us that we can be the very best for GSK, and importantly, for our patients and consumers. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

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