Principal Scientist, Rare Disease - Renal Disorders

Cambridge, Massachusetts
October 22 2021
Position Type
Full Time
Organization Type
Job Type
Staff Scientist
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

The Rare Disease Research Unit (RDRU) is part of Pfizer's Biotherapeutics in Pfizer Worldwide R&D. Pfizer's Non-Malignant Hematology Research within the RDRU focuses on developing multiple therapeutic approaches to develop new therapies for rare hematologic diseases and rare renal diseases. In this role, the Principal Scientist will have a strong focus on implementing and conducting nonclinical pharmacology studies across multiple therapeutic modalities to support portfolio entry and project advancement. The Principal Scientist will be part of a larger interdisciplinary team partnering closely with RDRU colleagues and partner lines and will be responsible for delivering high quality data to project teams. The ideal candidate will be a highly motivated, dynamic laboratory scientist with demonstrated experience and expertise working with disease models. The candidate is expected to work independently in the planning, execution, documentation, and the presentation of complex experiments contributing to development of new drug discovery projects while progressing existing programs.

  • Independently conceptualize, organize, and perform in vivo/ ex vivo/ in vitro studies to provide high quality laboratory-based investigative data to support project progression across multiple therapeutic modalities.
  • Design, develop and perform cell-based and biochemical assays.
  • Apply scientific expertise in drug discovery to advance programs.
  • Communicate experimental findings accurately and concisely in both oral and written formats.
  • Contribute to and aid in the development of project in a multidisciplinary team environment.
  • Work independently and collaboratively across various disciplines.
  • Build and facilitate internal and external collaborations.

  • Ph.D. with 5 years of post-Ph.D. experience in molecular and cellular biology, immunology, or related field
  • Research experience in renal biology or kidney disease.
  • Extensive experience with a broad spectrum of state-of-the-art cellular and biochemical assays, including novel method development, primary cell culture and the construction of models of disease.
  • The ability to work independently, and a demonstrated ability to contribute to multiple projects in parallel with scientific rigor and learning agility.
  • Strong written and verbal communication skills and ability to collaborate effectively with scientists working in other disciplines.
  • Strong track record of scientific accomplishments demonstrated through publications.
  • An understanding of drug discovery and development concepts.
  • Extensive practical experience working within cross-disciplinary teams and achieving results in a matrix environment.

    Other Job Details:
    • Eligible for Relocation Package
    • Eligible for Employee Referral Bonus
    • #LI-PFE

    Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

    Sunshine Act

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    EEO & Employment Eligibility

    Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

    Research and Development

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