Postdoctoral Fellow-Cancer Genetics and Epigenetics.

Duarte, California
October 14 2021
Position Type
Full Time
Organization Type
About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

Postdoctoral Fellow - Epigenetics and RNA modification

The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow in the laboratory of Dr. Yanzhong (Frankie) Yang at the Department of Cancer Genetics and Epigenetics. The research projects in Yang's lab focus on investigating the role of protein arginine methylation in the regulation of epigenetics and RNA metabolism, particularly RNA modification and splicing. Arginine methylation is one of the most abundant protein modifications. Importantly, the enzymes that catalyze arginine methylation, namely protein arginine methyltransferases (PRMTs), are essential for development and have emerged as novel drug targets for cancer treatment. The lab utilizes biochemistry, molecular and structural biology, as well as cellular and genetically modified mouse models to address some of the most fundamental questions in the field of epigenetics and RNA metabolism, in which arginine methylation plays a critical role. To know more about Yang lab's research, please refer to our recent publications (Mol Cell 40, 1016-1023 (2010); Mol Cell 53, 484-497 (2014); Nat Rev Cancer. 13, 37-50 (2013), Nat Commun. 6:6428 (2015), and EMBOJ e106309. doi: 10.15252, (2021)).

The ideal candidate should have extensive experience in biochemistry, molecular biology, and cell biology in the field of epigenetics and RNA metabolism. Skills with mouse models are preferred. The candidate should be self-motivated, with a proven track record of productivity.

Basic education, experience and skills required for consideration:

  • PhD in Biochemistry, Molecular Biology, and Cellular or Developmental Biology.
  • Strong interest in basic and translational research.
  • Strong work ethic, meticulous and detail-oriented record keeping habits.
  • Excellent written and verbal communication skills. Evidence of productivity reflected in first author publications in peer-reviewed journals.
  • Good problem solving skills and passion to follow relevant literature.
  • Ability to conduct independent research, and work effectively in a team.

City of Hope is committed to creating adiverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.


  • Posting Date: Feb 17, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job

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