Associate Director, Translational Oncology Lead

Boulder, Colorado
October 15 2021
Life Sciences, Oncology
Position Type
Full Time
Organization Type

As a member of the Boulder Translational Oncology group,the successful candidate will act as a core member of clinical development teams, this individual is responsible for developing and implementing a robust clinical biomarker plan that translates our preclinical knowledge into competitive strategies for programs moving into early clinical development, and driving bench to bedside and bedside to bench learning. The candidate will combine a deep understanding of cancer biology and cancer immunology, with experience in clinical trial sample analyses to design, prioritize and execute clinical biomarker studies that will inform key drug development decisions.

  • For assigned projects of moderate complexity, develop scientifically rigorous clinical translational research strategies focusing on pharmacodynamic proof-of-mechanism, patient selection/stratification, clinical proof-of-concept, and underlying disease biology related to mechanisms of drug sensitivity or resistance, and combinations.
  • Contributes clinical protocol, lab manual, informed consent, clinical study reports language specific to biomarkers, and communications including presentations and peer-reviewed publications.
  • Analyze, interpret and report results of clinical biomarker analyses, including support of regulatory filings.
  • Partner collaboratively across integrated, multi-functional clinical teams encompassing development (e.g. clinical, clinical pharmacology, statistics, development operations) and research (e.g. close interactions with biologists and computational scientists), clinical biomarker assay specialists, diagnostics and asset leaders while participating in a culture of scientific excellence and innovation.
  • Be a nexus for bedside to bench and bench to bedside learnings by communicating and leveraging findings broadly across the organization.
  • Assess state of the art technologies, collaborate closely with computational and systems biologists, and academic collaborators to expand clinical translational research.
  • Receives guidance from higher level colleagues on more complex projects; May seek guidance from the Head of Boulder Translational Oncology for the most complex projects.



Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
  • Advanced degree (PhD, Pharm. D.) or equivalent experience, with focus on cancer biology, cancer genetics and/or cancer immunology.
  • Minimum 5+ years of academic or industry experience required demonstrating experience and independence in designing, executing and interpreting studies of cancer biomarker in clinical trials including biomarker development, validation and clinical application; familiarity with clinical trial design, logistics and regulatory issues
  • Strong record of research productivity demonstrating an advanced and current understanding of cancer biology, cancer genetics and cancer immunology
  • Experience with computational, systems and statistical analysis such as scripting, Spotfire, or R programming.
  • Ability to drive interactions at the interface between lab bench-based research and early clinical development up to proof of concept studies.
  • Direct experience or familiarity with state-of-the-art technologies applicable to cancer biomarker or immune response analysis such as next-generation sequencing, immunohistochemistry, immunofluorescence, flow cytometry, in situ hybridization, gene expression profiling, and digital image analysis.
  • Demonstrated ability to think strategically and creatively while contributing to projects, thrive in a highly collaborative, multi-disciplinary team setting, highly effective verbal and written communication skills.

  • Experience with both cell-autonomous and tumor microenvironment mechanisms.
  • Demonstrated ability to thrive in matrix organizations.
  • Experience leveraging genomic and molecular information from patients with extraordinary responses in early stage clinical trials to guide clinical development.

  • Ability to support clinical teams across global time zones.
  • Up to 20% domestic and/or international travel may be required

Other Job Details

Eligible for Relocation Package

For roles based in Colorado:

The annual base salary for this position ranges from $118,900.00 to $198,100.00. In addition, this position offers an annual bonus with a target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

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