Associate Scientist II- In Vivo

Houston, Texas
October 14 2021
Health Sciences
Organization Type
The mission of The University of Texas M. D. Anderson Cancer Center is to eliminate cancer in Texas, the nation and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public.

The Associate Scientist II in Translational biology will be responsible for performing in vivo pharmacology studies to support preclinical development and translational biology of investigational therapeutics. Activities will include working with project teams through the execution of pharamacokinetic, pharmacodynamic and efficacy studies to evaluate exploratory through advanced therapeutics.


1. Under minimal supervision, designs and utilizes novel in vivo xenograft and allograft models.
2. Doses animals and analyzes the outcome of pharmacokinetic, pharmacodynamic and efficacy studies.
3. Performs survival and non-survival animal surgeries for specimen collection and characterization.
4. Utilizes non-invasive imaging.
5. Analyzes data and help with preparation of written and oral reports to project teams.
6. Assists in utilization of in vivo models.
7. Contributes to project team.
8. Employ safe lab practices.
9. Maintain research records and laboratory notes.


Required: Bachelor's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.

Education Preferred: Master's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.


Requried: One year of relevant research experience in lab. With preferred degree, no required experience.

1. In vivo pharmacology experience including animal handling, dosing, and conducting drug PK/PD and efficacy studies with mice is required.
2. Experience with in vivo models including subcutaneous and orthotopic xenografts and/or genetically engineered models of cancer.
3. Experience maintaining cell lines in tissue culture, preparing reagents and dosing solutions.
4. Hands-on experience administering test agents by gavage or intravenous and intraperitoneal injections required.
5. Ability to perform tumor measurements is essential.
6. Must have prior experience with minor animal survival and non-survival surgery for specimen collection and characterization.
7. Experience with in vivo imaging modalities and the evaluation of tissues and biological fluids for molecular and/or biochemical endpoints are desired.
8. The position requires a highly self-motivated individual, with outstanding organizational skills, the ability to effectively present results and conclusions to co-workers, collaborators and manager. Ability to work well under pressure and drive personal and team objectives that impact critical timelines is expected. A collaborative attitude is essential for this position.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.