Postdoctoral fellow positions are available in the Laboratory of Molecular Biology of the National Institute of Diabetes, Digestive, & Kidney diseases (NIDDK) in the National Institutes of Health. The current research is focused on protein quality control mechanisms safeguarding neuronal functions during aging. The fellow is expected to lead an independent research project, dissecting how eukaryotic cells cope with various disease-associated toxic proteins such as tau, A-beta, and alpha-synuclein using a combination of super-resolution live-cell imaging, genetic screens, genomic tools, structure-based functional assays, and fruit fly models. Examples of recently completed studies include the role of unconventional secretion of misfolded proteins in ceroid lipofuscinosis (Nat. Cell Biol. 2016 18(7):765-76; BioRxiv, 2021, doi: https://doi.org/10.1101/2021.07.16.452648), the processing of extracellular protein tau and alpha-synuclein aggregates (PNAS, 2020 117(20) 10865; Nature Communications, 2021 12(1)), and the role of ubiquitin-fold modifier (UFM1) in ribosome-associated quality control at the endoplasmic reticulum (Cell Research, 2020 30(1) 5-20). For more information, see
The NIH offers a competitive salary and an outstanding research environment with many opportunities to collaborate. NIH is an Equal Opportunity Employer and is dedicated to building a diverse community in its training and employment programs.
A Ph.D. degree with a strong publication record. Experiences in neurobiology and animal study are preferred but not required.
Interested candidates should send a CV with the names of three references and a Statement of Research Interest to Dr. Yihong Ye (firstname.lastname@example.org).
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