Senior Scientist, Biophysics

Boulder, Colorado
October 14 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

Pfizer Boulder R&D (formerly Array BioPharma), located in Boulder, CO, is focused on the discovery, development, and commercialization of targeted small molecule drugs to treat patients afflicted with cancer. The research group in Boulder was responsible for the recent development and launch of BRAFTOVI (encorafenib) and MEKTOVI (binimetinib) for patients with BRAF-mutant melanoma. These products have also been granted Breakthrough Therapy Designation by the FDA for BRAF-mutant colorectal cancer.

Based in Colorado, with more than 300 days a year of sunshine, Boulder is a paradise in the West! Visit to discover what we love about Boulder. Many colleagues live just outside of Boulder and have commutes of only 15 to 30 minutes.

The Structural Biology group at Pfizer Boulder R&D has an open position for a Senior Scientist-level biophysicist. Our highly collaborative team has expertise in molecular/cell biology, protein biochemistry, structural biology, and biophysics. As part of the team, the successful candidate will contribute to early drug discovery advancements and IND-enabling studies across multiple projects. The preferred candidate will have experience with, and a deep understanding of, the biophysical characterization of protein-small molecule interactions, including those that are challenging to interrogate. This individual will be highly motivated, innovative, excel in team environments, and have the ability to work in a fast-paced environment where projects and priorities shift quickly.

How You Will Achieve It

  • Design and execute biophysical assays and disseminate results that are critical to project advancement
  • Establish purification protocols and purify recombinant proteins from host cells
  • Document and communicate (written and oral) research priority, progress, and results with project teams
  • Provide technical and scientific guidance to junior research associates within the team



  • Doctoral degree (Biophysics, Biochemistry, Structural Biology or related field) with 0 - 2 years of postdoctoral experience or a Bachelor's/Master's degree with equivalent laboratory experience
  • Hands-on experience and a deep knowledge of leveraging SPR (Biacore preferred) to understand protein-small molecule interactions. This includes experimental design, assay optimization, and data analysis
  • Experience in the expression of recombinant proteins in E. coli systems and purification of challenging targets
  • Strong data analysis, problem-solving, communication, and organizational skills
  • Must have excellent interpersonal skills and embrace the ideas of others


  • Protein MS experience and knowledge of Agilent Q-TOF routine maintenance are highly desired
  • Excellent knowledge of other standard biophysical tools used to characterize protein-small molecule interactions including, but not limited to, MST, ITC, and DSF


Primary interactions of this position will be with Boulder colleagues within the Structural Biology group. Interdepartmental communication with Enzymology, Medicinal Chemistry, and Computational Chemistry will be common. Occasional interactions with external service vendors are also expected.

  • Able to lift 50lb objects with dimensions of 12 inches in height and 26 inches in width

  • Able to adhere to safe lab practices with appropriate PPE such as, but not limited to, safety goggles, face mask, gloves, lab coat/protective gowning, and closed-toe shoes
  • Able to work flexible hours occasionally when performing time-sensitive experiments

Other Job Details

Eligible for Relocation Package

Eligible for Employee Referral Bonus

For roles based in Colorado:

The annual base salary for this position ranges from $80,000.00 to $133,300.00. In addition, this position offers an annual bonus with a target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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