Sr. Principal Scientist-In Vivo Lead, Translational Sciences

La Jolla, California
October 14 2021
Position Type
Full Time
Organization Type
Job Type
Staff Scientist
Role Summary

We seek an accomplished Sr. Principal Scientist level oncology scientist to join the Translational Sciences group within the Oncology Research & Development (ORD), La Jolla, California. The successful candidate will join a dynamic team of scientists in the Oncology Translational Sciences Group, playing a leading role in guiding project teams in appropriate planning and use of pre-clinical models of cancer to evaluate new drug candidates, mechanisms, and targets.

The Sr. Principal Scientist/In Vivo Lead will participate in pre-clinical drug discovery and development programs with a focus on tumor intrinsic biology related to signal transduction, targeted therapeutics, and epigenetics. The successful candidate will be responsible for working with the project teams to design, plan and execute an in vivo strategy to ensure efficient and effective project decision-making. They will be a key contributor in the In Vivo Committee, responsible for presenting in vivo plans and obtaining peer input for protocol finalization and approval to meet research project objectives. The individual will directly supervise laboratory staff that make up an in vivo team responsible for study performance and data analysis and play a role in Translational Sciences Department strategy. The Sr. Principal Scientist will provide technical and scientific expertise in in vivo Pharmacology across ORD to enable target identification, validation, prioritization and efficient drug discovery. The candidate should have experience managing small teams with a track record of supervising and mentoring scientists. The Sr. Principal Scientist will demonstrate an ability to work within cross functional teams. Ideal applicants will possess excellent communication, leadership and organizational skills, an ability for "big picture" thinking, critical problem-solving abilities, and a commitment to excellence.

Role Responsibilities
  • Establish scientific in vivo strategy and study plans for drug discovery projects.
  • Track record of managing small teams and supervising/mentoring scientists.
  • Serve as the in vivo Pharmacology lead on several drug discovery projects.
  • Works within the multi-functional teams to support target identification, validation, drug discovery, and combination therapy.
  • Works across the in vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across Translational Sciences.
  • Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
  • Develop and characterize new in vivo mouse models including genetically engineered mouse (GEM) models to study biologic mechanisms and support exploration of novel cancer therapeutics. This will be achieved through leveraging the expertise of both internal and external thought leaders to develop models with greater clinical translatability.
  • Provide interpretation of model systems in the context of clinical translatability.
  • The Sr. Principal Scientist will generate and be accountable for the necessary Animal Use Protocols that ensures team members comply with all internal policies and regulatory requirements.
  • Drives data interpretation, presentation and documentation of experiments as well as preparation of study reports including drafting in vivo sections of regulatory documents such as IND filings. Responsible for contribution to relevant in vivo sections of study reports and regulatory documents, i.e. IND filings. Written and verbal presentation of results within a multidisciplinary team environment. Ensure that projects have all critical in vivo data to enable project stage dependent decisions. Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.
  • Possess excellent verbal and written communication skills to thrive in a fast-paced matrix environment.

Basic Qualifications
  • Ph.D. in Cancer Biology, Immunology, Biochemistry, Genetics or equivalent experience in a related discipline with > 8 years post Ph.D. industry experience with technical and scientific expertise in drug discovery and pre-clinical development.
  • Supervisory, mentoring and leadership experience required.
  • Experience in collaborative research in Oncology Drug Discovery programs.
  • Expertise in animal models of human cancer including CDX, PDX and syngeneic models required.
  • Expertise with GEMM and humanized models highly desirable. Hands on experience in in vivo skills (IV, PO dosing, blood/tissue collections).
  • Strong publication record in Tumor intrinsic biology or equivalent achievements in industry desired.
  • Excellent oral and written communication skills. Proficiency in all common and scientific software.
  • Candidate demonstrates a breadth of diverse leadership experiences and capabilities including the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Other Job Details
  • Eligible for Relocation Package
  • Eligible for Employee Referral Bonus
  • #LI-PFE

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

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Research and Development


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