Senior Associate Scientist, Tumor Evolution

La Jolla, California
October 14 2021
Position Type
Full Time
Organization Type
Job Type
Staff Scientist
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

Pfizer Oncology R&D is working to change the trajectory of cancer by translating breakthrough discoveries in cancer research into the best medicines imaginable for patients. The newly formed Tumor Fitness & Evolution group is focused on applying the latest scientific knowledge and novel approaches to discover truly innovative therapies for patients. We are seeking a Senior Associate Scientist at the BS/MS level who is passionate about cancer biology and wants to make an impactful contribution in understanding and targeting mechanisms of cell plasticity and drug resistance. Your job responsibilities will include performing and documenting lab-based research, employing critical thinking to design and interpret experiments, and communicating research findings to managers and relevant colleagues. As you work on projects, you will gain exposure to the broad Pfizer organization and learn from collaborations with cross-functional teams.

How You Will Achieve It

  • Design and execute key experiments to address the basic and translational biology of novel drug targets, their molecular pathways, and their connection to human disease
  • Develop tools for advancing group projects, including cell models of disease (2D/3D), CRISPR technologies, characterization of small molecule inhibitors, and biomarkers
  • Perform functional assays such as proliferation readouts, biomarker analysis using qPCR, western blots, high-content imaging, and flow cytometry
  • Collaborate with colleagues within and across departments to help advance projects
  • Effectively communicate experiment results to team


  • B.S. in Cell or Molecular Biology (or a comparable biological science) with minimum of 3+ years relevant post-degree experience or MS with 0+ years of experience
  • Past research activities in areas of tumor biology, such as therapeutic resistance, epigenetics, DNA damage/repair, or oncogenic driver signaling
  • Experience with mammalian cell culture and genetic modulation (CRISPR, siRNA/shRNA, and/or lentivirus)
  • Experience performing cell-based assays to assess target modulation and measure downstream signaling pathways, for example: qRT-PCR, Western blotting, ELISA, ChIP, multi-color flow cytometry, or immunofluorescence.
  • Enthusiasm to learn new technologies and proactively engage with colleagues
  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic


  • Experience with GraphPad Prism, DepMap, cBioPortal, UCSC Genome Browser
  • Drug discovery experience

  • Must be able to wear standard laboratory PPE (lab coat/safety shoes/glasses/etc.) and perform lifting of items (less than 10 lbs)

  • Last Date to Apply: October 27, 2021

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development


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