Senior Research Scientist I, Drug Metabolism

Foster City
See job description.
October 14 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist

Senior Research Scientist I, Drug Metabolism
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gileads therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the companys five core values. Thats because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

Gilead Sciences, Inc. is a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead's therapeutic areas of focus include viral diseases (such as HIV/AIDS, hepatitis, COVID and other respiratory viruses), cancer and inflammation and is headquartered in Foster City, California.

Specific Responsibilities:

The primary responsibility of this position is to design and monitor or conduct experiments to understand the absorption, distribution, metabolism and excretion (ADME) and drug-drug interaction (DDI) properties of drug candidates. The scientist will also serve as a drug metabolism and pharmacokinetic (DMPK) representative on multidisciplinary project teams and provide guidance to solve ADME liabilities. Supervision of other scientists and/or laboratory staff would likely be required.

Essential Duties and Job Responsibilities:

  • Serve as DMPK subject matter expert for multiple dynamic cross-functional teams, to define ADME strategies to achieve target product profiles, integrate in vitro and in vivo drug disposition data, interpretation, and give presentations to teams.
  • Work closely with internal and external resources to assure timely delivery of high quality DMPK data.
  • An advantage would be the ability to design and perform complex PK analyses, carry out model development and PK/PD analyses to answer translational questions, and to provide DMPK guidance for project teams.
  • Provide clear verbal communication of results and strategies at group, department, project team and management level. Write research reports and regulatory documents.
  • Contribute to science through conference presentations and publication of new findings.

Knowledge, Experience and Skills:

  • Requires a highly motivated individual with PhD degree in life sciences with 3 to 5 years of post-doctoral and/or industry experience.
  • Demonstrates excellent scientific verbal and technical communication, and interpersonal skills. Must be organized, pay attention to details and have strong organizational and planning skills.
  • Requires hands-on experience and deep knowledge of pharmacokinetics, biotransformation, enzymology, transporter sciences or related pharmacology.
  • Expertise and experience in one or more of the following areas:
    • Experience in drug development, authoring documents for regulatory authorities
    • State of the art bioanalysis by LC/MS and related techniques
    • Metabolite identification and understanding of reactive metabolite chemistry
    • Biochemical and cell-based approaches to study the metabolism and/or transport of drug candidates
    • Understand the principles, theories and approaches of pharmacokinetics, drug disposition and drug interactions. Proven application of modeling methods for quantitative translation using Simcyp, GastroPlus and/or general kinetic modeling programs.
    • Bioanalysis and disposition processes of therapeutic proteins

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact for assistance.

For more information about equal employment opportunity protections, please view the EEO is the Law' poster.



Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

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