Principal Scientist (Director), Drug Metabolism and Pharmacokinetics

Location
Foster City
Salary
See job description.
Posted
October 10 2021
Ref
R0019738
Position Type
Full Time
Organization Type
Pharma
Job Type
Senior Scientist


Principal Scientist (Director), Drug Metabolism and Pharmacokinetics
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gileads therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the companys five core values. Thats because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

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Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company\'s mission is to advance the care of patients suffering from life-threatening diseases worldwide. Headquartered in Foster City, California, Gilead has operations in North America, Europe and Australia.

Specific Responsibilities:

The primary responsibility of this Drug Metabolism and Pharmacokinetic (DMPK) scientist is to serve as a biotransformation expert. This job role will focus on providing guidance to drug discovery project teams, defining candidate selection strategies, and continue through drug development phases to registration/post approval.

Essential Duties and Job Responsibilities:

  • Work closely with internal and external resources to assure high quality and timely delivery of nonclinical and clinical biotransformation data for molecules in discovery and development.
  • Design and perform complex analysis to characterize biotransformation and disposition of drugs.
  • Serve as DMPK subject matter expert on dynamic cross-functional teams, provide in vitro and in vivo drug disposition data, interpretation and presentations to teams.
  • Able to communicate and educate others on complex areas of drug biotransformation as a technical expert.
  • Supervising associate and research scientists may be needed.
  • Make major contributions to scientific literature and conferences through publication and presentation of research results.


Knowledge, Experience and Skills:

  • Requires a highly motivated individual with a PhD degree in life sciences with 10+ years of industry experience.
  • Prior experience contributing to the discovery and development of drug candidates from pre-clinical through clinical trials.
  • Considered an expert in metabolic routes of biotransformation and metabolite identification demonstrated through presentation/publication record
  • Demonstrates excellent scientific verbal, technical communication and interpersonal skills. Must be organized, pay attention to details and have strong planning skills.
  • Comfortable working with and educating colleagues in drug metabolism, toxicology and clinical pharmacology on strategies to understand drug metabolism and disposition
  • Expertise and experience in the following areas:
    • Lead design and execution of nonclinical and clinical radio- and non-radiolabeled ADME studies. Serve as an expert resource; accommodate the wide range of experience to ensure radiolabel placement, develop protocols and placement of studies.
    • Work with contract research organizations (CROs) to ensure timely execution; ensure high-quality impactful data; provide close scrutiny of the radioanalysis/profiling/identification data.
    • Provide oversight and integration of the data and data-reports. Proactively manage to resolve data gaps. Ensure reports are written to communicate clear messages and ready for regulatory submissions.

For jobs in the United States:

As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans\' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

Following extensive monitoring, research, consideration of business implications and advice from internal and external experts, Gilead has made the decision to require all U.S. employees and contractors to receive the COVID-19 vaccines as a condition of employment. Full vaccination is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.\u200b

For more information about equal employment opportunity protections, please view the EEO is the Law' poster.

NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT
YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT

PAY TRANSPARENCY NONDISCRIMINATION PROVISION

Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.
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To apply, visit https://gilead.wd1.myworkdayjobs.com/en-US/gileadcareers/job/United-States---California---Foster-City/Principal-Scientist--Director---Drug-Metabolism-and-Pharmacokinetics_R0019738-1





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