GSK

Investigator - LC-MS Protein Characterization

Employer
GSK
Location
Collegeville, PA
Salary
Competitive
Posted
August 16 2021
Ref
301503
Discipline
Other, Other
Organization Type
Pharma
Site Name: USA - Pennsylvania - Upper Providence Posted Date: Aug 16 2021 GlaxoSmithKline has an immediate opening for an Investigator position - LC-MS and protein characterization in Collegeville, PA. The mass spectrometry group is well equipped with modern instrumentation including Synapt G2S with both H/DX and IM, Xevo G2-XS, Orbitrap Fusion Tribrid, Orbitrap XL, Exploris 480, Eclipse Tribrid, Q Exactive Plus, 2D-NanoUPLC, Nano-UPLC, UPLC and many other supporting instrumentation and associated data analysis software. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following… Developing mass spec-based strategies & methods (e.g. LC-MS and LC-MS/MS) Perform analysis for the characterization and comparability evaluation of therapeutic proteins. Apply advanced methods and techniques, including immunoprecipitations and/or other small-scale purifications Develop other analytical and/or biochemical methods to deepen the understanding of protein structure -function relationships Participate in supporting clinical studies through commercial biopharmaceutical process development and manufacturing. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: MS with 5+ years of experience in biotech or pharmaceutical industry or a Ph.D. Experience in protein characterization mass spectrometry, with hands-on experience on various high-resolution accurate mass LC-MS instruments operation, nano-LC fluidics and LC-MS/MS methods, data processing software and workflows. Experience in mass spectrometry instrumentation, maintenance, and troubleshooting Experience in developing cutting-edge LC-MS/MS workflows for therapeutic proteins including mAbs, ADCs, and bispecifics is highly desirable. Experience with co-formulations would be a plus. Preferred Qualifications: If you have the following characteristics, it would be a plus: Experience in analysis of protein therapeutics using platform assays like intact/reduced, peptide mapping and advanced/novel technologies Scientific working knowledge in the structure and function of protein therapeutics Knowledge and hands-on experience in various separation techniques such as immunoprecipitation or other in vitro purification, CE, SEC, IEX and HPLC/UPLC Experience supporting FTIH through commercial stage of biopharmaceutical development The candidate is expected to be highly motivated with excellent communication skills, both written and verbal. Candidate should be an instinctive team player with excellent people skills. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. *This is a job description to aide in the job posting, but does not include all job evaluation details. #GSKBiopharm_Development *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. 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