Senior Director / Director DMPK Project Specialist
Site Name: USA - Pennsylvania - Upper Providence, UK - Hertfordshire - Stevenage Posted Date: Aug 5 2021 The global DMPK organization at GSK is looking for a Senior Director/Director to head up the global DMPK Project Specialist group. This group is responsible for DMPK representation in all GSK pipeline projects across the different R&D sites. The individual will lead this global group and ensure that our DMPK science is embedded in projects from early Discovery to late-stage Development. As a senior leader in the DMPK organization, reporting to the VP, DMPK, the candidate needs to ensure that project specialists are applying world class science to drive a translational understanding of drug disposition and PKPD in projects in a collaborative manner with key stakeholders in other organizations. This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following: KEY RESPONSIBILITIES Lead the global DMPK Project Specialist group across multiple R&D sites. Drive best practice sharing across the team in support of global DMPK strategic direction. Develop and maintain excellent working relations with key stakeholders in GSK R&D, in order to ensure strategic alignment and optimal cross-functional collaboration and communication. Ensure that translational PKPD approaches and appropriate screening cascades with multiparametric optimization are being applied in Discovery projects in collaboration with other groups in DMPK. Responsible for coordinating and ensuring high-quality DMPK contributions to regulatory filings and internal project review documentation. Ensure the use of state-of-the-art mechanistic ADME and PBPK modeling approaches in Development projects together with other groups in DMPK as well as other stakeholders. Efficiently manage demand and capacity of the DMPK Project Specialist group to ensure optimal support of all projects in the GSK pipeline. Develop and grow talent to build a high-performing DMPK Project Specialist group. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: PhD in field relevant to DMPK (e.g. Pharmacology, Biochemistry, Pharmacokinetics or Drug Metabolism) At least 10 years of industry experience Experience managing cross-matrix teams, with demonstrated experience in strategy development. Experience engaging with external DMPK science community and consortia; demonstrated ability to work with key opinion leaders. Ability to manage budgets and resources. Ability to coach/mentor, develop and performance-manage staff. Preferred Qualifications: The ideal candidate will be/have: Demonstrated ability to develop and maintain strong relationships and build partnerships with stakeholders. Demonstrated ability to apply state-of-the-art DMPK science in projects to enable the discovery of drug candidates and the successful development of new medicines. In-depth experience in DMPK representation in Discovery and Development projects with different modalities (e.g. small molecule, mAb) through excellent communication skills and collaboration. Experience in applying state-of-the-art DMPK concepts in the successful discovery of drug candidates through efficient screening cascades such as multiparametric optimization, translational PKPD and human dose optimization strategies. Extensive knowledge in regulatory filings and regulatory interactions/communication. Experience in leveraging modeling approaches and predictive science in Discovery and Development projects to accelerate timelines and increase probability of success. An enthusiastic leader with a proven track record to build and lead high-performing teams. *LI-GSK Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigour and risk, governance and control, managing ambiguity and paradox. Managing individual performance. Creating a performance culture and driving results, prioritisation, execution, delivering performance. Setting strategic direction and leading on-going organisational transformation. Building a resilient organisation. Building strong relationships and collaboration in service of common goals, engaging the organisation and building trusted external networks for mutual benefit. 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