GSK

Investigator

Employer
GSK
Location
Collegeville, PA
Salary
Competitive
Posted
September 30 2021
Ref
299198
Discipline
Other, Other
Organization Type
Pharma
Site Name: USA - Pennsylvania - Upper Providence Posted Date: Sep 30 2021 We have an exciting opportunity for a highly motivated, agile and experienced scientist with lab level expertise in genomic technologies to join the Cellular Biomarkers Genomics group within the Bioanalysis, Immunogenicity and Biomarkers (BIB) department based in Collegeville, PA. Our group is responsible for developing genomics biomarker assays for use in clinical studies. This individual will serve as a technical expert in applied genomic technologies and will generate data to support the understanding of disease heterogeneity, drug's mechanism of action, and patient response to treatment at the molecular level through application of advanced genomic technologies, including Next Generation Sequencing (NGS), single cell analysis, Nanostring, qPCR, etc. This role will conduct and oversee all aspects of the method development, trouble-shooting, validation and sample analysis for clinical studies requiring genomic technologies endpoints including reagent selection/optimization, sample preparation, sample acquisition and data processing. They will ensure all work is conducted in compliance with GCLP regulations and follows the appropriate SOPs. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following… Generate high quality data to support clinical studies by NGS platforms Conduct and oversee all aspects of method development, troubleshooting, validation and sample analysis for clinical studies Support single cell immuno-genomics works such as CITE-seq and Abseq (for example, cell preparation and library preparation) Handle human biological samples and perform experimental work in accordance with safety requirements, data integrity and GCLP guidelines. Collaborate with Biomarker Leads and provide biomarker assay support to deliver on biomarker strategy as defined by project needs. Develop genomic assays using applied genomic technologies to support clinical studies; delivery of robust, high quality data packages Work with data management, programming and bioinformatics scientists to expedite the transfer of biomarker data to clinical teams Deliver, interpret and communicate complex, high quality scientific data to project/program teams within agreed timelines Handle multiple projects concurrently Contribute to biomarker strategy and capital equipment discussions Act as subject matter expert for the transfer of assays to CROs Help lead efforts to investigate novel genomics and data analysis platforms and imbed within the organization Willingness to develop and train others as required Why you? Basic Qualifications: PhD in Molecular Biology, Biochemistry or related filed with minimum 2 years post-PhD experience B.S./M.S. degree with minimum 10 years post-graduation experience in genomics, NGS, molecular or cellular biology, biomedical science or related disciplines Knowledge of current genomic analytical platforms (e.g., RNA-Seq, microbiome, qPCR, Nanostring) Experience in designing, troubleshooting and implementing single cell RNA-seq applications or similar high content techniques (e.g., BD Rhapsody, 10x Genomics) Knowledge of flow cytometry and histotechology to lead cross-platform genomics projects (e.g. CITE-Seq, TCR/BCR Seq, Nanostring assays etc.) Experience and understanding in the use of genomics analysis software (Partek Genomics suite, CLC-Bio etc) Experience working with tight deadlines, both independently and in a team Knowledge of the drug development process Preferred Qualifications: If you have the following characteristics, it would be a plus: Ability to provide guidance on the use of NGS, digital quantification of nucleic acids and single cell analysis to support clinical sample testing Ability to maintain a disciplined approach, ensuring a relentless focus on quality, compliance, scientific rigor and operational excellence Attention to detail, good communication, documentation skills, ability to problem solve and troubleshoot Highly motivated team player with a proactive attitude and ability to interact effectively within a multi-disciplinary team Demonstrated judgment and decision making, especially for prioritizing multiple requests Collaboration and interpersonal skills to work well with colleagues from all phases of clinical drug development and influence biomarker testing strategies Hands on experience with the NovaSeq, MiSeq, 10X chromium and BD Rhapsody Strong track record in sample preparation, single cell library preparation, sequencing and analysis (CITE-seq, Abseq and/or REAP-seq) Experience in the development and validation of novel genomic assays to support clinical measurements and their translation to a companion diagnostic (CDx) when applicable. Experience of working with external vendors for the transfer of assay to support clinical trial sample analysis and development of CDx Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

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