Senior Scientist, In Vivo (Oncology)
Site Name: USA - Pennsylvania - Upper Providence Posted Date: Aug 20 2021 Are you energized by a challenging role in the Tumor Cell Targeting (TCT) Research Unit, where scientific demand is driving team growth? If so, this Sr. Scientist role would be a great opportunity to consider We are seeking a highly motivated, enthusiastic and skilled in vivo scientist to join the in vivo pharmacology team within GSK Oncology's Tumor Cell Targeting (TCT) Research Unit located in Upper Providence, PA. The mission of the TCT RU is to selectively target cancer cells to deliver transformational anti-cancer efficacy with a positive therapeutic index by leveraging a variety of therapeutic modalities including, but not limited to, small molecules and antibodies. In this laboratory-based position, you will participate in drug discovery program teams where you will design, conduct, interpret, and present the results of in vivo preclinical studies thus making important contributions to the drug discovery and translational medicine efforts in support of TCT RU programs. This role will provide YOU the opportunity to lead key activities to progress YOUR career. building understanding and contributing to in vivo pharmacology for oncology drug discovery practical experience to conduct in vivo pharmacology studies (in vivo tumor model development, maximum tolerated dose (MTD), PK/PD relationship and efficacy) in mouse tumor models mature public speaking through presentation of experimental design, methods, and findings. summarizing the key scientific findings in regulatory reports and manuscripts partner and communicate with a wide range of internal and external stakeholders. leadership skills Why You? Basic Qualifications: MS (or BS with equivalent experience / expertise) with 3+ years of relevant industry or academic experience in in vivo oncology Three or more years experience with mouse handling, dosing, caliper tumor measurements, and tissue sampling skills enabling the ability to independently conduct in vivo studies assessing tumor growth, efficacy and PK/PD of pharmacological agents in xenograft and/or syngeneic mouse tumor models One or more years experience in adopting new methods and protocols related to in vivo and ex vivo experiments Preferred Qualifications: Experience with syngeneic tumor models Experience with ex vivo tissue processing and aseptic cell culture technique (human and murine primary or/and cancer cell lines) Attention to detail and proficient reasoning skills in experimental design, data analysis and interpretation The candidate must be highly motivated with excellent communication skills and demonstrated ability to work in a team and matrix environment Must have problem-solving abilities, resourceful, able to work in a fast-paced team environment and be flexible about the roles Experience with rodent surgeries, orthotopic oncology models and humanized mouse models Experience with cell biology techniques e.g. IHC, western blotting, ELISA and flow cytometry Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. 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