GSK

Sr. Scientist, in vivo Biology

Employer
GSK
Location
Collegeville, PA
Salary
Competitive
Posted
October 05 2021
Ref
307681
Organization Type
Pharma
Job Type
Senior Scientist
Site Name: USA - Pennsylvania - Upper Providence Posted Date: Oct 5 2021 We are seeking a scientist with experience in metabolism, cardiovascular, renal, and/or neuroscience research either in academia or industry. This biologist will join an energetic team in the GSK Novel Human Genetics Research Unit (NHG RU) with the goal of discovering and developing medicines for diseases with a significant unmet medical need. In this position the laboratory-based scientist will conduct integrative pharmacology experiments that drive the discovery of medicines. The scientists will support preclinical efforts for target validation/lead optimization and may also support clinical programs. This is an exciting bench-based role in a dynamic matrix team environment that will allow the successful candidate to have a critical contribution in our drug discovery efforts. The successful candidate will have knowledge, understanding and experience in state of the art metabolism, cardiovascular, renal, and/or neuroscience in vivo models. Only a talented individual, who aspires to learn and work collaboratively in teams will succeed in this role. Though drug discovery experience is highly desirable, this is not essential. The successful candidate will be one who is science driven, innovative, understands project needs and establishes relevant biological assays, effectively trouble shoots challenges, assumes personal accountability, and is courageous. The candidate must be keen to learn through experience, in order to advance in their career. This role will provide you with the opportunity to lead key activities to progress your career. The responsibilities of this role include the following: Deliver pharmacology experiments in rodents to support drug discovery programs across multiple therapeutic areas (metabolism, cardiovascular, renal, neurodegeneration). Able to design, establish, conduct, and validate in vivo assays. Experience in methods to measure metabolism, cardiovascular/renal function, and/or behavior. Experience in generating, recording, analyzing, and presenting data. Skills in interpreting results and drawing conclusions through independent working and with supervision. Able to resolve scientific and technical challenges and deliver results efficiently. Maintain knowledge of relevant literature and effectively incorporate knowledge. Assimilate and evaluate in-house and publicly available data in support of projects. Effective communication (both verbal and written) of scientific ideas and results to internal groups and project teams. Ability to work independently as well as in a matrix environment. About NHG RU: The Novel Human Genetics Research Unit (NHG RU) was formed in 2019 to identify and advance novel targets with high genetic association to disease. This is based on the observation that targets with high human genetic evidence supporting their causal role in a disease state improves success in drug discovery by two-fold. The NHG RU is therapeutically broad and complements other research units within GSK which have strategic focuses on immunology and oncology. The current portfolio includes projects focused on cardiovascular, renal, and metabolic diseases including heart failure and liver disease in addition to neurological diseases including Parkinson's, Alzheimer's, ALS, FTD, migraine and pain. The remit of NHG RU is to identify novel targets based on human genetics, develop assets for clinical studies, and perform Phase 1 first-time in human and proof of mechanism studies in the clinic. This goal is enabled through strategic external and GSK-internal partnerships. Why you? Basic Qualifications: Bachelor of Science degree in biology, physiology, pharmacology, or related area 2 years of in vivo research experience either in industry or an academic environment Experience in rodent handling and use in experimentation, dosing, formulation, tissue harvest, and blood sampling. Exposure to a range of in vivo biology techniques including those for the measurement of metabolism, cardiovascular function, renal function, inflammation, and/or neurodegneration Proficiency with Microsoft Office software and maintaining laboratory notebooks Excellent analytical, problem-solving, communication, and organizational skills Preferred Qualifications: Demonstrated experience in establishing robust rodent PK/PD and efficacy models Proficiency in models of cardiovascular, renal, metabolic, and/or neurodegenerative disease. Surgical skills in recovery and non-recovery rodents Knowledge of in vitro cell model systems (cell lines, primary cells, iPSCs) and techniques (molecular biology, cell biology and biochemistry) Ability to prioritize, manage time efficiently, and implement creative solutions to meet program needs. Proficiency in GraphPad Prism Commitment to continual improvement by reading and applying the latest scientific literature, methodologies and technologies. Resourceful, takes initiative, adept, versatile, and resilient. Ability to adapt to changing priorities. Prior experience in drug discovery either at pharma or in biotech. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, and Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Agile decision-making - using evidence and applying judgement to balance pace, rigor and risk, managing ambiguity and paradox. Creating a performance culture and driving results, prioritisation, and execution Building strong relationships and collaboration in common goals, engaging the organisation and building trusted external networks for mutual benefit. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continually looking for opportunities to learn, build skills and share learning both internally and externally. Building strong relationships and collaboration, and managing trusted stakeholder relationships both internally and externally. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. At GSK, the health and safety of our employees are of paramount importance. As a science-led healthcare company on a mission to get ahead of disease together, we believe that supporting vaccination against COVID-19 is the single best thing we can do in the US to ensure the health and safety of our employees, complementary workers, workplaces, customers, consumers, communities, and the patients we serve. GSK has made the decision to require all US employees to be fully vaccinated against COVID-19, where allowed by state or local law and where vaccine supply is readily available. The only exceptions to this requirement are employees who are approved for an accommodation for religious, medical or disability-related reasons. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

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