Postdoctoral position to study Polo kinase, centrosome organization, cell division, & tumorigenesis
Investigating the role of Polo kinases orchestrating centrosomal organization, cell division, cell signaling, and tumorigenesis using biochemical, cell biological, and structural approaches
Position Description: A postdoctoral fellowship is available to study the function of mammalian polo-like kinase 4 and 1 (Plk4 and Plk1) that play central roles in regulating various biological events, including centriole duplication, bipolar spindle formation, chromosome segregation, cell division, and proliferation. Dysregulation of Plk4/Plk1-dependent processes is tightly linked to the development of aneuploidy and cancer. During the past several years, we have been taking biochemical and cell biological approaches, including super-resolution imaging, single molecule tracking, and in vitro reconstitution to delineate the molecular bases of governing Plk4/Plk1’s functionality on the centrosomal architecture, the deregulation of which can lead to the development of many human diseases, including cancers. For additional information. please visit https://ccr.cancer.gov/staff-directory/kyung-s-lee.
Fellows who have an expertise in the field of biochemistry and cell biology with a keen interest in learning about the organization and function of the centrosome and their relevance to pathophysiological disorders are encouraged to apply. Applicants should have a Ph.D. (or expected to receive a Ph.D.) or M.D. equivalent at the time of joining the lab and have achieved the degree less than 3 years ago.
To apply, please send CV and three names of references to Dr. Kyung Lee (firstname.lastname@example.org). Starts at $59,900 for fellows with 0 yr postdoc training (+ annual raise) and full health insurance
Employer Name: National Cancer Institute, NIH.
Position Location: 9000 Rockville Pike, Bethesda, MD 20892, U. S. A.
- Kim, T.-S., et al., 2019. Molecular architecture of a cylindrical self-assembly at human centrosomes. Nat. Comm. 10: 1151. Featured article (Editors’ Highlights).
- Park, J.-E., et al., 2019. Phase separation of polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis. Nat. Comm. 10: 4959.
- Wei, Z., et al., 2020. Requirement of the Cep57-Cep63 interaction for proper Cep152 recruitment and centriole duplication. Mol. Cell. Biol. 40:e00535. Featured article (Cover art)
- Ahn, J. I., et al., 2020. Phase separation and versatile capacity of pericentriolar scaffold proteins drive the formation of higher-order self-assemblies at human centrosomes. Cell Cycle. Nov 18:1-21.
- Lee, K. S., et al., 2020. A self-assembled cylindrical platform for Plk4-induced centriole biogenesis. Open Biol. 10:200102 (Review). Featured article (Cover art)
Disclaimer: This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.
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