Postdoctoral Fellow - DNA Replication and Repair

Location
Duarte, California
Salary
Competitive
Posted
October 01 2021
Ref
10011470-2
Discipline
Life Sciences
Position Type
Full Time
Organization Type
Healthcare/Hospital
About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.

Position Summary

Postdoctoral positions are now available in the laboratory of Dr. Yilun Liu at the Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope. Dr. Liu's research focus relates to (1) dissecting the mechanism by which cells prevent the formation of endogenous DNA breaks as a consequence of unresolved collision between a replication fork and a transcription machinery or a transcription-induced R-loop; (2) developing pharmaceutical mechanisms for cancer therapy by targeting enzymes important for resolving R-loops or transcription-replication collisions to enhance DNA break formation as well as factors important for the BRCA2 and PARP-dependent repair pathways to keep these DNA breaks unrepaired; and (3) targeting mitochondrial DNA as signaling molecule in immune response and cancer therapy.

Basic education, experience and skills required for consideration:
  • A Ph.D. degree in life or biomedical sciences, or a related discipline is required.
  • Experience in biochemistry and/or cell biology is preferred

Additional Information:
  • For more information on Dr. Yilun Liu's research please visit, here .
  • Dr. Liu's group has published in journals, including Nature Communications, Cell Reports, EMBO Journal and PNAS. A full list of publications can be found here .
  • To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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  • Posting Date: Jun 4, 2021
  • Job Field: Research
  • Employee Status: Regular
  • Shift: Day Job

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