Senior Scientist/Principal Scientist, Protein Chemistry – Large Molecule Drug Discovery

South San Francisco, California
September 29 2021
Position Type
Full Time
Organization Type
Job Type
Senior Scientist

Join a Team that Lives to Improve Lives

People come to Genentech from across disciplines and across the world to solve our most challenging medical conditions. You’ll find inspiration in our passion for biotechnology, our purpose to positively impact the lives of millions of patients and our dedication to our people. Joining Genentech means being part of a tradition of inquiry that will change the world. It means embracing our failures as much as our successes. It requires a willingness to look beyond the edge of what's possible. And a focus on doing the day-to-day work that makes great science happen.

The following opportunity exists in South San Francisco:

Senior Scientist/Principal Scientist, Protein Chemistry – Large Molecule Drug Discovery


We are seeking a talented Scientist/ Senior Scientist to join the Department of Protein Chemistry – Large Molecule Drug Discovery at Genentech. We are looking for a candidate to build oligonucleotide therapeutics discovery capabilities within the research drug discovery pipeline at Genentech. The candidate must have a proven record of accomplishments in antisense oligonucleotides, RNAi, or microRNA discovery and the ability to build and champion this therapeutic modality within the research organization at Genentech. Experience in delivery of oligonucleotide therapeutics, large molecule drug discovery, or bioconjugation would be preferred. Experience in early development of oligonucleotide therapeutics is highly desired. The candidate will lead a research lab and interface across different therapeutic areas, including neuroscience, immunology and oncology, to help build a comprehensive therapeutic discovery strategy. The position requires effective participation in multidisciplinary teams with biology, in vivo pharmacology, assay development and safety assessment scientists. The candidate will be expected to function as molecule and project team lead on pipeline projects and exceptionally strong leadership and communications skills will be essential for this position.


The qualified individual will possess a Ph.D. in a biological science with at least 2-8 years of relevant experience in academia, biotechnology and/or pharmaceutical industry and possess a record of accomplishments and publications in a relevant scientific discipline. The position requires a track record in oligonucleotide therapeutics discovery and hands-on working knowledge of oligonucleotide chemistry. Relevant experience in protein engineering, structural biology, or biochemistry is desirable. The candidate will have experience in drug discovery and development, as well as a deep commitment to working as part of teams to deliver breakthrough medicines. Job level will be based on prior experience and accomplishment.

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

The next step is yours. To apply today, click on the "Apply for this job" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page. If you are in need of an accommodation due to a disability to assist with submitting your application or at any point during the hiring process, please email

Similar jobs

Similar jobs