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Senior Research Scientist II, Drug Metabolism

Employer
Gilead Sciences, Inc.
Location
Foster City
Salary
See job description.
Closing date
Oct 19, 2021

View more

Discipline
Health Sciences, Drug Development
Position Type
Full Time
Job Type
Other
Organization Type
All Industry, Pharma


Senior Research Scientist II, Drug Metabolism
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gileads therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the companys five core values. Thats because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

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Specific Responsibilities:

The primary responsibility of this pharmacokinetic (PK) scientist is to serve as a PK and drug metabolism and pharmacokinetic (DMPK) representative and provide guidance to drug discovery project teams and after candidate selection continue with project through drug development phases to registration/post approval. Apply knowledge in primary area of expertise broadly to benefit department across the portfolio.

Essential Duties and Job Responsibilities:

  • Serve as DMPK subject matter expert on dynamic cross-functional teams, to define absorption, distribution, metabolism and excretion (ADME) strategy to achieve target product profile, provide in vitro and in vivo drug disposition and PK drug-drug interaction (DDI) data, interpretation and presentations to teams.
  • Work closely with internal and external resources to assure a high level of quality and timely delivery of DMPK support.
  • Design and perform complex PK analysis, model development and PK/PD analyses to answer translational questions and to provide DMPK guidance for project teams.
  • Makes major contributions to scientific literature and conferences through publication and presentation of research results.
  • Ability to communicate and educate others on complex areas of ADME science as a technical expert. Could be a deep expert in one area with working knowledge of other aspects of drug disposition.
  • Supervising associate scientists may be required.


Knowledge, Experience and Skills:

  • Requires a highly motivated individual with PhD degree in life sciences with 5-10 years of industry experience.
  • Demonstrates excellent scientific verbal, technical communication and interpersonal skills. Must be organized, pay attention to details and have strong organizational and planning skills.
  • Prior experience contributing to the discovery and development of a drug candidate from preclinical through clinical trials
  • Considered an expert in one or more subdisciplines of ADME or bioanalytical sciences demonstrated through presentation/publication record
  • Comfortable working with and educating colleagues in medicinal chemistry, DMPK, toxicology and clinical pharmacology on strategies to understand drug PK, metabolism and disposition
  • Expertise and Experience in one or more of the following areas:
    • Capability in the state-of-the-art bioanalysis with previous experience in applying automation to enable high throughput bioanalysis
    • DMPK related enzymology and transport, biotransformation and reactive metabolite chemistry.
    • Principles and theories on PK and ADME science, applying such knowledge to the direction that supports the advancement of drug candidates



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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans\' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com opens new window" target="_blank" href="https://apptrkr.com/get_redirect.php?id=2521076&targetURL=mailto:careers@gilead.com">careers@gilead.com for assistance.

Following extensive monitoring, research, consideration of business implications and advice from internal and external experts, Gilead has made the decision to require all U.S. employees and contractors to receive the COVID-19 vaccines as a condition of employment. Full vaccination is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.\u200b

For more information about equal employment opportunity protections, please view the EEO is the Law' poster.

NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT
YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT

PAY TRANSPARENCY NONDISCRIMINATION PROVISION

Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.
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To apply, visit https://gilead.wd1.myworkdayjobs.com/en-US/gileadcareers/job/United-States---California---Foster-City/Senior-Research-Scientist-II--Drug-Metabolism_R0022615-1





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